Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

Cheng Xu; Sixiang Shi; Liangzhu Feng; Feng Chen; Stephen A. Graves; Emily B. Ehlerding; Shreya Goel; Haiyan Sun; Christopher G. England; Robert J. Nickles; Zhuang Liu; Taihong Wang; Weibo Cai

doi:10.1039/c5nr09193d

Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

Cheng Xu, Sixiang Shi, Liangzhu Feng, Feng Chen, Stephen A. Graves, Emily B. Ehlerding, Shreya Goel, Haiyan Sun, Christopher G. England, Robert J. Nickles, Zhuang Liu, Taihong Wang, Weibo Cai

Research output: Journal article publication › Journal article › Academic research › peer-review

65 Citations (Scopus)

Abstract

Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO-IONP-^1stPEG-^2ndPEG). The nanoconjugates exhibited a prolonged blood circulation half-life (∼27.7 h) and remarkable tumor accumulation (>11 %ID g^-1) via an enhanced permeability and retention (EPR) effect. Due to the strong near-infrared absorbance and superparamagnetism of RGO-IONP-^1stPEG-^2ndPEG, multimodality imaging combining positron emission tomography (PET) imaging with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest the great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future.

Original language	English
Pages (from-to)	12683-12692
Number of pages	10
Journal	Nanoscale
Volume	8
Issue number	25
Early online date	25 Apr 2016
DOIs	https://doi.org/10.1039/c5nr09193d
Publication status	Published - 7 Jul 2016
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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10.1039/c5nr09193d

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title = "Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging",

abstract = "Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO-IONP-1stPEG-2ndPEG). The nanoconjugates exhibited a prolonged blood circulation half-life (∼27.7 h) and remarkable tumor accumulation (>11 %ID g-1) via an enhanced permeability and retention (EPR) effect. Due to the strong near-infrared absorbance and superparamagnetism of RGO-IONP-1stPEG-2ndPEG, multimodality imaging combining positron emission tomography (PET) imaging with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest the great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future.",

author = "Cheng Xu and Sixiang Shi and Liangzhu Feng and Feng Chen and Graves, {Stephen A.} and Ehlerding, {Emily B.} and Shreya Goel and Haiyan Sun and England, {Christopher G.} and Nickles, {Robert J.} and Zhuang Liu and Taihong Wang and Weibo Cai",

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doi = "10.1039/c5nr09193d",

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T1 - Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

AU - Xu, Cheng

AU - Shi, Sixiang

AU - Feng, Liangzhu

AU - Chen, Feng

AU - Graves, Stephen A.

AU - Ehlerding, Emily B.

AU - Goel, Shreya

AU - Sun, Haiyan

AU - England, Christopher G.

AU - Nickles, Robert J.

AU - Liu, Zhuang

AU - Wang, Taihong

AU - Cai, Weibo

PY - 2016/7/7

Y1 - 2016/7/7

N2 - Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO-IONP-1stPEG-2ndPEG). The nanoconjugates exhibited a prolonged blood circulation half-life (∼27.7 h) and remarkable tumor accumulation (>11 %ID g-1) via an enhanced permeability and retention (EPR) effect. Due to the strong near-infrared absorbance and superparamagnetism of RGO-IONP-1stPEG-2ndPEG, multimodality imaging combining positron emission tomography (PET) imaging with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest the great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future.

AB - Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO-IONP-1stPEG-2ndPEG). The nanoconjugates exhibited a prolonged blood circulation half-life (∼27.7 h) and remarkable tumor accumulation (>11 %ID g-1) via an enhanced permeability and retention (EPR) effect. Due to the strong near-infrared absorbance and superparamagnetism of RGO-IONP-1stPEG-2ndPEG, multimodality imaging combining positron emission tomography (PET) imaging with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest the great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future.

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U2 - 10.1039/c5nr09193d

DO - 10.1039/c5nr09193d

M3 - Journal article

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AN - SCOPUS:84976433779

SN - 2040-3364

VL - 8

SP - 12683

EP - 12692

JO - Nanoscale

JF - Nanoscale

IS - 25

ER -

Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging

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