In the previous work, the LoG (Laplacian of Gaussian) signal that is the earliest stage output of human visual neural system was suggested to be useful in image quality assessment (IQA) model design. This work considered that LoG signal carried crucial structural information of IQA in the position of its zero-crossing and proposed a Non-shift Edge (NSE) based IQA model. In this study, we focus on another aspect of the properties of the LoG signal, i.e., LoG whitens the power spectrum of natural images. Here our interest is that: when exposed to unnatural images, specifically distorted images, how does the HVS whitening this type of signals In this paper, we first investigate the whitening filter for natural image and distorted image respectively, and then suggest that the LoG is also a whitening filter for distorted images to some extent. Based on this fact, we deploy the LOG signal in the task of IQA model design by applying two very simple distance metrics, i.e., the MSE (mean square error) and the correlation. The proposed models are analyzed according to the evaluation performance on three subjective databases. The experimental results validate the usability of the LoG signal in IQA model design and that the proposed models stay in the state-of-the-art IQA models.