@inbook{da11b0c7d8364598b89dacde557d5f31,
title = "Liver-Specific Delivery of Sleeping Beauty Transposon System by Hydrodynamic Injection for Cancer Gene Validation",
abstract = "Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening of candidate liver cancer driver genes. Manipulating their expression level using a reverse genetic mouse model involving hydrodynamic tail-vein injection delivery can rapidly elucidate the role of these candidate genes in liver cancer tumorigenesis.",
keywords = "Cancer gene discovery, Cancer gene validation, Gene delivery, Hydrodynamic tail-vein injection, Sleeping Beauty transposon system",
author = "Chiu, {Amy P.} and Keng, {Vincent W.}",
year = "2019",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-8967-6_15",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "185--196",
booktitle = "Methods in Molecular Biology",
}
