Liver cancer stem cells: Implications for a new therapeutic target

Kin Wah Lee, Antonia Castilho, Stephanie Ma, Irene Oi Lin Ng

Research output: Journal article publicationReview articleAcademic researchpeer-review

72 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.
Original languageEnglish
Pages (from-to)955-965
Number of pages11
JournalLiver International
Volume29
Issue number7
DOIs
Publication statusPublished - 20 Jul 2009
Externally publishedYes

Keywords

  • Bone marrow cells
  • CSCs
  • HCC
  • Hepatocytes
  • Oval cells

ASJC Scopus subject areas

  • Hepatology

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