Liver cancer stem cells: Implications for a new therapeutic target

Kin Wah Lee; Antonia Castilho; Stephanie Ma; Irene Oi Lin Ng

doi:10.1111/j.1478-3231.2009.02040.x

Liver cancer stem cells: Implications for a new therapeutic target

Kin Wah Lee, Antonia Castilho, Stephanie Ma, Irene Oi Lin Ng

Research output: Journal article publication › Review article › Academic research › peer-review

82 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.

Original language	English
Pages (from-to)	955-965
Number of pages	11
Journal	Liver International
Volume	29
Issue number	7
DOIs	https://doi.org/10.1111/j.1478-3231.2009.02040.x
Publication status	Published - 20 Jul 2009
Externally published	Yes

Keywords

Bone marrow cells
CSCs
HCC
Hepatocytes
Oval cells

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1111/j.1478-3231.2009.02040.x

Cite this

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title = "Liver cancer stem cells: Implications for a new therapeutic target",

abstract = "Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.",

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T1 - Liver cancer stem cells: Implications for a new therapeutic target

AU - Lee, Kin Wah

AU - Castilho, Antonia

AU - Ma, Stephanie

AU - Ng, Irene Oi Lin

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Y1 - 2009/7/20

N2 - Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.

AB - Hepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.

KW - Bone marrow cells

KW - CSCs

KW - HCC

KW - Hepatocytes

KW - Oval cells

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DO - 10.1111/j.1478-3231.2009.02040.x

M3 - Review article

C2 - 19490415

SN - 1478-3223

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JO - Liver International

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Liver cancer stem cells: Implications for a new therapeutic target

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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