Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

Z. Q. Lei; L. Li; G. J. Li; Chi Wah Leung; J. Shi; C. M. Wong; K. C. Lo; W. K. Chan; C. S.K. Mak; S. B. Chan; N. M.M. Chan; C. H. Leung; P. T. Lai; P. W.T. Pong

doi:10.1063/1.3676212

Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

Z. Q. Lei
, L. Li
, G. J. Li
, Chi Wah Leung
, J. Shi
, C. M. Wong
, K. C. Lo
, W. K. Chan
, C. S.K. Mak
, S. B. Chan
, N. M.M. Chan
, C. H. Leung
, P. T. Lai
, P. W.T. Pong

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

39 Citations (Scopus)

Abstract

We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm2possess tunneling magnetoresistance (TMR) of 122 and sensitivity of0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.

Original language	English
Article number	07E505
Journal	Journal of Applied Physics
Volume	111
Issue number	7
DOIs	https://doi.org/10.1063/1.3676212
Publication status	Published - 1 Apr 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Physics and Astronomy

More information

10.1063/1.3676212

http://hdl.handle.net/10397/5076

Cite this

Lei, Z. Q., Li, L., Li, G. J., Leung, C. W., Shi, J., Wong, C. M., Lo, K. C., Chan, W. K., Mak, C. S. K., Chan, S. B., Chan, N. M. M., Leung, C. H., Lai, P. T., & Pong, P. W. T. (2012). Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors. Journal of Applied Physics, 111(7), Article 07E505. https://doi.org/10.1063/1.3676212

@article{026c63ae516c4cd09fc54f214b727c9a,

title = "Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors",

abstract = "We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm2possess tunneling magnetoresistance (TMR) of 122 and sensitivity of0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.",

author = "Lei, \{Z. Q.\} and L. Li and Li, \{G. J.\} and Leung, \{Chi Wah\} and J. Shi and Wong, \{C. M.\} and Lo, \{K. C.\} and Chan, \{W. K.\} and Mak, \{C. S.K.\} and Chan, \{S. B.\} and Chan, \{N. M.M.\} and Leung, \{C. H.\} and Lai, \{P. T.\} and Pong, \{P. W.T.\}",

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doi = "10.1063/1.3676212",

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T1 - Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

AU - Lei, Z. Q.

AU - Li, L.

AU - Li, G. J.

AU - Leung, Chi Wah

AU - Shi, J.

AU - Wong, C. M.

AU - Lo, K. C.

AU - Chan, W. K.

AU - Mak, C. S.K.

AU - Chan, S. B.

AU - Chan, N. M.M.

AU - Leung, C. H.

AU - Lai, P. T.

AU - Pong, P. W.T.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm2possess tunneling magnetoresistance (TMR) of 122 and sensitivity of0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.

AB - We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm2possess tunneling magnetoresistance (TMR) of 122 and sensitivity of0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.

UR - https://www.scopus.com/pages/publications/84861728395

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DO - 10.1063/1.3676212

M3 - Journal article

SN - 0021-8979

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JO - Journal of Applied Physics

JF - Journal of Applied Physics

IS - 7

M1 - 07E505

ER -

Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

Abstract

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