Limited Impact of Social Isolation on Alzheimer-Like Symptoms in a Triple Transgenic Mouse Model

Susanna Pietropaolo, Yan Sun, Ruixi Li, Corinne Brana, Joram Feldon, Kay Yan Benjamin Yee

Research output: Journal article publicationJournal articleAcademic researchpeer-review

47 Citations (Scopus)


Gene-environment interactions are known to play a major role in the ethiopathology of several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study investigates whether environmental manipulations, that is, social isolation, may affect the genetic predisposition to develop AD-related traits in a triple transgenic mouse model (3 × Tg-AD), as suggested by our previous study employing physical exercise (Pietropaolo et al., 2008). Mutant and wild type mice of both sexes were housed singly or in groups from weaning, and evaluated behaviorally at 6 to 7 months of age. Independent of sex, the 3 × Tg-AD genotype was associated with enhanced acoustic startle response, improved performance in the cued version of the water maze and a clear impairment in the Y maze. Notably, the female (but not male) mutant mice showed increased anxiety. Although social isolation was effective in modifying several behaviors, it did not exacerbate any of the AD-like symptoms. Our findings demonstrated the differential susceptibility of the 3 × Tg-AD mouse line to environmental manipulations, showing that social isolation did not induce remarkable effects on the genetically determined AD-like symptoms, in contrast to what previously observed with physical exercise.
Original languageEnglish
Pages (from-to)181-195
Number of pages15
JournalBehavioral Neuroscience
Issue number1
Publication statusPublished - 1 Feb 2009
Externally publishedYes


  • acoustic startle response
  • anxiety
  • gene-environment interactions
  • sex differences
  • spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience


Dive into the research topics of 'Limited Impact of Social Isolation on Alzheimer-Like Symptoms in a Triple Transgenic Mouse Model'. Together they form a unique fingerprint.

Cite this