Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy

Keyphrases

• Neuronal Injury 100%
• Hippocampal Neurons 100%
• Ligustilide 100%
• Parkin-mediated Mitophagy 100%
• Cerebral Ischemia-reperfusion 100%
• PINK1-Parkin Pathway 100%
• Mitophagy 90%
• Cerebral Ischemia-reperfusion Injury 50%
• Reperfusion 30%
• Transient Middle Cerebral Artery Occlusion (tMCAO) 20%
• Neuroprotection 20%
• Mitochondrial Function 20%
• Ischemia Stroke 20%
• Fluorescence Microscope 10%
• Ischemia 10%
• Hippocampus 10%
• Transmission Electron Microscope 10%
• Western Blot 10%
• Protein Expression 10%
• Behaviour Score 10%
• Brain Injury 10%
• In Vitro Model 10%
• Ischemia-reperfusion Injury 10%
• Mitochondrial Membrane Potential 10%
• Neuroprotective Effect 10%
• Eosin Staining 10%
• Hematoxylin Staining 10%
• Mitochondrial Dysfunction 10%
• Therapeutic Strategies 10%
• Na+-K+ ATPase 10%
• Neurological Behavior 10%
• Neuroprotective Activity 10%
• Oxygen-glucose Deprivation 10%
• Mitochondrial Damage 10%
• Natural Compounds 10%
• Ligusticum Chuanxiong 10%
• Membrane Activity 10%
• Cell Transfection 10%
• Angelica Sinensis (Oliv.) Diels 10%
• 2,3,5-triphenyltetrazolium Chloride 10%
• Mitochondrial Division 10%

Neuroscience

• Ligustilide 100%
• Parkin 100%
• Brain Ischemia 100%
• Mitophagy 100%
• Cerebral Ischemia-Reperfusion Injury 35%
• Ischemia 28%
• Mitochondrial Function 14%
• Staining Technique 14%
• Neuroprotection 14%
• Neuroprotective Agent 14%
• In Vitro 14%
• Middle Cerebral Artery 14%
• Cerebrovascular Accident 14%
• In Vivo 7%
• Mitochondrion 7%
• Hippocampus 7%
• Western Blot 7%
• Transfection 7%
• Behavior (Neuroscience) 7%
• Natural Product 7%
• Protein Expression 7%
• Mitochondrial Membrane Potential 7%
• Adenosine Triphosphatase (Potassium Sodium) 7%
• Haematoxylin 7%
• Electron Microscope 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Brain Ischemia 100%
• Ligustilide 100%
• Parkin 100%
• Reperfusion Injury 50%
• Ischemia 40%
• Neuroprotection 20%
• Cerebrovascular Accident 20%
• Middle Cerebral Artery Occlusion 20%
• Neuroprotective Agent 20%
• Ligusticum chuanxiong 10%
• Western Blot 10%
• Angelica Sinensis 10%
• Natural Product 10%
• Sodium Ion 10%
• Adenosine Triphosphatase 10%
• Potassium Ion 10%
• Triphenyltetrazolium 10%
• Eosin 10%
• Haematoxylin 10%