The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-β-O-4'-conifery ether(1), lirioresinol A(2), 1-hydroxypinoresinol(3), 5-methoxybalanophonin(4), balanophonin(5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol(6), and p-hydroxybenzaldehyde(7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7(1×10-12-1×10-7mol·L-1) increased UMR106 cell proliferation to some extent.
- Sambucus williamsii
- UMR106 cell
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Complementary and alternative medicine
- Pharmacology (medical)