Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells

Meng Meng Xu; Ying Hui Duan; Hui Hui Xiao; Yi Dai; Zhen Zhong Wang; Man Sau Wong; Xin Sheng Yao; Wei Xiao

doi:10.4268/cjcmm20141418

Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells

Meng Meng Xu, Ying Hui Duan, Hui Hui Xiao, Yi Dai, Zhen Zhong Wang, Man Sau Wong, Xin Sheng Yao, Wei Xiao

Research output: Journal article publication › Journal article › Academic research › peer-review

7 Citations (Scopus)

Abstract

The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-β-O-4'-conifery ether(1), lirioresinol A(2), 1-hydroxypinoresinol(3), 5-methoxybalanophonin(4), balanophonin(5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol(6), and p-hydroxybenzaldehyde(7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7(1×10-12-1×10-7mol·L-1) increased UMR106 cell proliferation to some extent.

Original language	English
Pages (from-to)	2684-2688
Number of pages	5
Journal	Zhongguo Zhongyao Zazhi
Volume	39
Issue number	14
DOIs	https://doi.org/10.4268/cjcmm20141418
Publication status	Published - 15 Jul 2014

Keywords

Lignans
Proliferation
Sambucus williamsii
UMR106 cell

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Complementary and alternative medicine
Pharmacology (medical)

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10.4268/cjcmm20141418

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abstract = "The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-β-O-4'-conifery ether(1), lirioresinol A(2), 1-hydroxypinoresinol(3), 5-methoxybalanophonin(4), balanophonin(5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol(6), and p-hydroxybenzaldehyde(7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7(1×10-12-1×10-7mol·L-1) increased UMR106 cell proliferation to some extent.",

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AU - Dai, Yi

AU - Wang, Zhen Zhong

AU - Wong, Man Sau

AU - Yao, Xin Sheng

AU - Xiao, Wei

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Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells

Abstract

Keywords

ASJC Scopus subject areas

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