Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells

Meng Meng Xu, Ying Hui Duan, Hui Hui Xiao, Yi Dai, Zhen Zhong Wang, Man Sau Wong, Xin Sheng Yao, Wei Xiao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)

Abstract

The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-β-O-4'-conifery ether(1), lirioresinol A(2), 1-hydroxypinoresinol(3), 5-methoxybalanophonin(4), balanophonin(5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol(6), and p-hydroxybenzaldehyde(7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7(1×10-12-1×10-7mol·L-1) increased UMR106 cell proliferation to some extent.
Original languageEnglish
Pages (from-to)2684-2688
Number of pages5
JournalZhongguo Zhongyao Zazhi
Volume39
Issue number14
DOIs
Publication statusPublished - 15 Jul 2014

Keywords

  • Lignans
  • Proliferation
  • Sambucus williamsii
  • UMR106 cell

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Complementary and alternative medicine
  • Pharmacology (medical)

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