Lignans from the stems of Sambucus williamsii and their effects on osteoblastic UMR106 cells

Xu Juan Yang, Man Sau Wong, Nai Li Wang, Sun Chi Chan, Xin Sheng Yao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)

Abstract

Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3- methoxyphenyl)-2-[4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy] -1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)- 2-[4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-[2, 3-dihydro-3-hydroxymethyl-7- hydroxy-5-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-benzofuranyl]-2, 6-dimethoxyphenoxy}-1-(4- hydroxy-3-methoxyphenyl) -1, 3-propanediol), along with seven known ones, including (-)-syringaresinol (1), (-)-pinoresinol (2), 1, 2-bis(4-hydroxy-3-methoxy phenyl)-1, 3-propanediol (3), (-)-erythro-1-(4- hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy propanyl)-2-methoxyphenoxy]-1, 3-propanediol (4), (-)-threo-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3- hydroxypropanyl)-2-methoxy phenoxy]-1, 3-propanediol (5), (-)-lariciresinol (6) and (-)-dihydrodehydrodiconiferyl alcohol (7), were isolated from the 60% ethanol extract of stems of Sambucus williamsii Hance by chromatographic methods. Their structures were established by spectral analysis. The effects of isolated compounds on the osteoblast-like UMR106 cell proliferation and ALP activities were determined. Compounds 2, 7 and 10 showed stimulating effects both on UMR106 cell proliferation and ALP activity. Compounds 1, 3, 6 and 8 stimulated UMR106 cell proliferation, while compounds 4 and 5 induced ALP activity in UMR106 cell.
Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalJournal of Asian Natural Products Research
Volume9
Issue number7
DOIs
Publication statusPublished - 1 Oct 2007

Keywords

  • ALP activity
  • Caprifoliaceae
  • Lignans
  • Proliferation
  • Sambucus williamsii
  • UMR106 cell

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this