@article{b985bfd13aac48cea604ff863eff9a3d,
title = "Ligand Control of Palladium-Catalyzed Site-Selective α- and γ-Arylation of α,β-Unsaturated Ketones with (Hetero)aryl Halides",
abstract = "This study describes the first palladium-catalyzed, site-selective α- and γ-arylation of α,β-unsaturated ketones with (hetero)aryl halides. A wide range of hetero(aryl)halides coupled with α,β-unsaturated ketones, and transformation into the arylated products proceeded with excellent to good yields. The site selectivity of the reaction is switchable by simply changing the phosphine ligand to access either α-arylated or γ-arylated products in good to excellent yields by using a low catalyst loading, and the method demonstrates good functional-group compatibility.",
keywords = "arylation, cross-coupling, ketones, ligand design, synthetic methods",
author = "Yuen, {On Ying} and So, {Chau Ming}",
note = "Funding Information: We thank the Research Grants Council of Hong Kong, Early Career Scheme (ECS 25301819), National Natural Science Foundation of China (21972122), and the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20180306173843318) for financial support. We are grateful to Prof. Tamio Hayashi (NTHU) for helpful discussions on this manuscript, Ms. Shan Shan Ng (PolyU) for her assistance in supporting material preparation, and Mr. Junyu Wu (PolyU) for his assistance in preparing some aryl halides. Funding Information: We thank the Research Grants Council of Hong Kong, Early Career Scheme (ECS 25301819), National Natural Science Foundation of China (21972122), and the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20180306173843318) for financial support. We are grateful to Prof. Tamio Hayashi (NTHU) for helpful discussions on this manuscript, Ms. Shan Shan Ng (PolyU) for her assistance in supporting material preparation, and Mr. Junyu Wu (PolyU) for his assistance in preparing some aryl halides. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",
year = "2020",
month = dec,
day = "21",
doi = "10.1002/anie.202010682",
language = "English",
volume = "59",
pages = "23438--23444",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "52",
}