Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

C. H. Chui; Hang Mei Polly Leung; F. Y. Lau; T. S.K. Wan; L. C. Chan; G. Cheng

Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

C. H. Chui, Hang Mei Polly Leung, F. Y. Lau, T. S.K. Wan, L. C. Chan, G. Cheng

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

Stem cell factor is a haemopoietic growth factor that interacts with the c-iiY-encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Hong Kong Medical Journal
Volume	4
Issue number	1
Publication status	Published - 1 Jan 1998

Keywords

Acute
Blotting
Leukemia
Myelocytic
Myelodysplastic syndromes
Proto-oncogene proteins c-kit/genetics
Southern
Stem cell factor

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia",

abstract = "Stem cell factor is a haemopoietic growth factor that interacts with the c-iiY-encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.",

keywords = "Acute, Blotting, Leukemia, Myelocytic, Myelodysplastic syndromes, Proto-oncogene proteins c-kit/genetics, Southern, Stem cell factor",

author = "Chui, {C. H.} and Leung, {Hang Mei Polly} and Lau, {F. Y.} and Wan, {T. S.K.} and Chan, {L. C.} and G. Cheng",

year = "1998",

month = jan,

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language = "English",

volume = "4",

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journal = "Hong Kong Medical Journal",

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publisher = "Hong Kong Academy of Medicine Press",

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Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia. / Chui, C. H.; Leung, Hang Mei Polly; Lau, F. Y. et al.
In: Hong Kong Medical Journal, Vol. 4, No. 1, 01.01.1998, p. 27-30.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

AU - Chui, C. H.

AU - Leung, Hang Mei Polly

AU - Lau, F. Y.

AU - Wan, T. S.K.

AU - Chan, L. C.

AU - Cheng, G.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Stem cell factor is a haemopoietic growth factor that interacts with the c-iiY-encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.

AB - Stem cell factor is a haemopoietic growth factor that interacts with the c-iiY-encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.

KW - Acute

KW - Blotting

KW - Leukemia

KW - Myelocytic

KW - Myelodysplastic syndromes

KW - Proto-oncogene proteins c-kit/genetics

KW - Southern

KW - Stem cell factor

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M3 - Journal article

SN - 1024-2708

VL - 4

SP - 27

EP - 30

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 1

ER -

Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

Abstract

Keywords

ASJC Scopus subject areas

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