Lack of structural rearrangement in c-kit and stem cell factor genes in Hong Kong Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia

C. H. Chui, Hang Mei Polly Leung, F. Y. Lau, T. S.K. Wan, L. C. Chan, G. Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Stem cell factor is a haemopoietic growth factor that interacts with the c-iiY-encoded transmembrane tyrosine kinase receptor during signal transduction in haemopoietic progenitor stem cells. We have screened 127 Chinese patients with myelodysplastic syndromes or acute myeloid leukaemia for structural rearrangements in the stem cell factor and c-kit genes using Southern blot analysis. No structural rearrangements were detected in any of the bone marrow samples that were tested. It seems that structural rearrangements in the stem cell factor and c-kit genes are rare in Hong Kong patients who have a haematological malignancy.
Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalHong Kong Medical Journal
Volume4
Issue number1
Publication statusPublished - 1 Jan 1998

Keywords

  • Acute
  • Blotting
  • Leukemia
  • Myelocytic
  • Myelodysplastic syndromes
  • Proto-oncogene proteins c-kit/genetics
  • Southern
  • Stem cell factor

ASJC Scopus subject areas

  • Medicine(all)

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