Label-free DNA sensor based on organic thin film transistors

Feng Yan, Sheung Man Mok, Jinjiang Yu, Helen L.W. Chan, Mo Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

85 Citations (Scopus)

Abstract

Organic thin film transistors (OTFTs) are excellent candidates for the application on disposable sensors due to their potentially low-cost fabrication process. A novel DNA sensor based on OTFTs with semiconducting polymer poly(3-hexylthiophene) has been fabricated by solution process. Both single- and double-strand DNA molecules are immobilized on the surface of the Au source/drain electrodes of different OTFT devices, producing a dramatic change in the performance of the devices, which is attributed to the increase of the contact resistances at the source/drain electrodes. Single-strand DNA and double-strand DNA are differentiated successfully in the experiments indicating that this is a promising technique for sensing DNA hybridization without labelling.
Original languageEnglish
Pages (from-to)1241-1245
Number of pages5
JournalBiosensors and Bioelectronics
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • DNA sensor
  • Organic semiconductor
  • Organic thin film transistor

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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