TY - JOUR
T1 - Ketamine-dependent neuronal activation in healthy volunteers
AU - Höflich, A.
AU - Hahn, A.
AU - Küblböck, M.
AU - Kranz, Georg
AU - Vanicek, T.
AU - Ganger, S.
AU - Spies, M.
AU - Windischberger, C.
AU - Kasper, S.
AU - Winkler, D.
AU - Lanzenberger, R.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - © 2016, Springer-Verlag Berlin Heidelberg. Over the last years, a number of studies have been conducted to clarify the neurobiological correlates of ketamine application. However, comprehensive information regarding the influence of ketamine on cortical activity is still lacking. Using resting-state functional MRI and integrating pharmacokinetic information, a double-blind, randomized, placebo-controlled, crossover study was performed to determine the effects of ketamine on neuronal activation. During a 55 min resting-state fMRI scan, esketamine (Ketanest S®) was administered intravenously to 35 healthy volunteers. Neural activation as indicated by the BOLD signal using the pharmacokinetic curve of ketamine plasma levels as a regressor was computed. Compared with placebo, ketamine-dependent increases of neural activation were observed in the midcingulate cortex, the dorsal part of the anterior cingulate cortex, the insula bilaterally, and the thalamus (t values ranging between 5.95-9.78, p < 0.05; FWE-corrected). A significant decrease of neural activation in the ketamine condition compared to placebo was found in a cluster within the subgenual/subcallosal part of the anterior cingulate cortex, the orbitofrontal cortex and the gyrus rectus (t = 7.81, p < 0.05, FWE-corrected). Using an approach combining pharmacological and fMRI data, important information about the neurobiological correlates of the clinical antidepressant effects of ketamine could be revealed.
AB - © 2016, Springer-Verlag Berlin Heidelberg. Over the last years, a number of studies have been conducted to clarify the neurobiological correlates of ketamine application. However, comprehensive information regarding the influence of ketamine on cortical activity is still lacking. Using resting-state functional MRI and integrating pharmacokinetic information, a double-blind, randomized, placebo-controlled, crossover study was performed to determine the effects of ketamine on neuronal activation. During a 55 min resting-state fMRI scan, esketamine (Ketanest S®) was administered intravenously to 35 healthy volunteers. Neural activation as indicated by the BOLD signal using the pharmacokinetic curve of ketamine plasma levels as a regressor was computed. Compared with placebo, ketamine-dependent increases of neural activation were observed in the midcingulate cortex, the dorsal part of the anterior cingulate cortex, the insula bilaterally, and the thalamus (t values ranging between 5.95-9.78, p < 0.05; FWE-corrected). A significant decrease of neural activation in the ketamine condition compared to placebo was found in a cluster within the subgenual/subcallosal part of the anterior cingulate cortex, the orbitofrontal cortex and the gyrus rectus (t = 7.81, p < 0.05, FWE-corrected). Using an approach combining pharmacological and fMRI data, important information about the neurobiological correlates of the clinical antidepressant effects of ketamine could be revealed.
KW - Anterior cingulate gyrus
KW - fMRI
KW - Insula
KW - Ketamine
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?scp=84984820151&partnerID=8YFLogxK
U2 - 10.1007/s00429-016-1291-0
DO - 10.1007/s00429-016-1291-0
M3 - Journal article
C2 - 27578365
VL - 222
SP - 1533
EP - 1542
JO - Referate und Beiträge zur Anatomie und Entwickelungsgeschichte
JF - Referate und Beiträge zur Anatomie und Entwickelungsgeschichte
SN - 0177-5154
IS - 3
ER -