@article{19ea18f7817b426f8ecaca6f723cac1a,
title = "Ionically crosslinked complex gels loaded with oleic acid-containing vesicles for transdermal drug delivery",
abstract = "Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2, 3, 5, 4'-tetrahydroxystilbene 2-O-Β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases.",
keywords = "Gel, Skin permeation, Transdermal delivery, Transdermal flux, Vesicles",
author = "Lai, {Wing Fu} and Ryan Tang and Wong, {Wing Tak}",
note = "Funding Information: Transdermal drug delivery is a non-invasive and user-friendly method for administration of therapeutic agents; however, partly due to the presence of the stratum corneum, which serves as a rate limiting barrier in transdermal permeation of most drugs [36], the practical use of transdermal drug delivery is impeded in the clinical context. From the data presented in this study, oleic acid-containing vesicles can effectively disrupt the integrity of the stratum corneum to enhance skin permeation of THSG, while showing good stability and negligible cytotoxicity. Upon the loading of the vesicles into a complex gel, which displays composition-dependent swelling and erosion behavior, a transdermal delivery system exhibiting tunable transdermal flux of THSG is obtained. It is hoped that with further optimization of the vesicle composition and with more detailed evaluation of the bioavailability of different drugs delivered by using the vesicles as carriers, a biocompatible, Aeaustyho-tro-Cmoanktreibauntdio tnusn: abCloen scyesptteumal iczaantiobne manaddemaevtahioldabolloeg fyo,r Wro.u-Ft.iLn.eatnradnsWd.e-Trm.Wa.;l dsruupgerdveisliivone,rypirnojtehcet administrationfuture. and funding acquisition, W.-F.L.; investigation, R.T. and W.-F.L. All authors have read and agreed to the published version of the manuscript. Author Contributions: Conceptualization and methodology, W.F.L. and W.T.W.; supervision, project administration and funding acquisition, W.F.L.; investigation, R.T. and W.F.L. All authors have read and agreed Ctoh tihnee speuUbnliisvheerds ivtyerosfioHno onfgthKeo mnga,nSuhsecnrizphte. n (PF01001421, and UDF01001421), and Research Grants Council of the Government of Hong Kong Special Administrative Region (C5012-15E). Funding: This research was funded by the Science, Technology and Innovation Commission of Shenzhen Conflicts of Interest: The authors declare no conflict of interest. Municipality (JCYJ20170818102436104), Natural Science Foundation of Guangdong Province (2018A030310485), Chinese University of Hong Kong, Shenzhen (PF01001421, and UDF01001421), and Research Grants Council of Referencesthe Government of Hong Kong Special Administrative Region (C5012-15E). Funding Information: This research was funded by the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20170818102436104), Natural Science Foundation of Guangdong Province (2018A030310485), Chinese University of Hong Kong, Shenzhen (PF01001421, and UDF01001421), and Research Grants Council of the Government of Hong Kong Special Administrative Region (C5012-15E). Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = aug,
doi = "10.3390/pharmaceutics12080725",
language = "English",
volume = "12",
pages = "1--11",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",
}