Investigating the psychometric properties of the EQ-5D-Y-3L, EQ-5D-Y-5L, CHU-9D, and PedsQL in children and adolescents with osteogenesis imperfecta

Richard Huan Xu, Liling Zhu, Rongjia Sun, Rachel Tan, Nan Luo, Sainan Zou (Corresponding Author), Dong Dong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

The objective of this study was to evaluate and compare the psychometric properties of the EQ-5D-Y-3L, EQ-5D-Y-5L, CHU-9D, and PedsQL, in a sample of children and adolescents with osteogenesis imperfecta (OI). A web-based cross-sectional survey was conducted among Chinese children and adolescents with OI in 2021. The EQ-5D-Y-3L, EQ-5D-Y-5L, CHU-9D, and PedsQL were used to assess the health-related quality of life for the participants. Construct validity, including convergent and divergent validity, known-group validity, and test–retest reliability, was examined to assess the psychometric properties of the measures. A total of 157 pediatric OI patients self-completed the questionnaire. Few of them reported the full health status. A strong ceiling effect was observed for all dimensions on the EQ-5D-Y and most on CHU-9D. Most dimensions of the EQ-5D-Y and CHU-9D showed statistically significant correlations with the hypothesized PedsQL subscales. The test–retest reliability for the EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU-9D was acceptable. The EQ-5D-Y-5L showed a better known-group validity than EQ-5D-Y-3L, CHU-9D, and PedsQL in differentiating patients in risk groups. Conclusion: The results confirmed that the EQ-5D-Y and CHU-9D are reliable and valid in pediatric OI patients. The EQ-5D-Y-5L performed better than EQ-5D-Y-3L regarding acceptability, convergent validity, and discriminatory power.What is Known:• Performance of the preference-based measures has never been reported in patients with Osteogenesis imperfecta.What

Original languageEnglish
Pages (from-to)4049-4058
Number of pages10
JournalEuropean Journal of Pediatrics
Volume181
Issue number12
DOIs
Publication statusPublished - Dec 2022

Keywords

  • CHU-9D
  • EQ-5D-Y
  • Health-related quality of life
  • Osteogenesis Imperfecta
  • PedsQL
  • Psychometric properties

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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