@article{81b3e9c410934da48e0351430fca538a,
title = "Intrinsically zirconium-89-labeled manganese oxide nanoparticles for in vivo dual-modality positron emission tomography and magnetic resonance imaging",
abstract = " Manganese-based nanoparticles (NPs) have recently attracted much attention in the field of biomedical imaging due to their impressive enhanced T1 contrast ability. Although the reported manganese-based NPs have exhibited good imaging capabilities as contrast agents, it is still urgent to develop novel multifunctional manganese-based imaging probes for future biomedical imaging, especially PET/MRI probes. Herein, we present chelator-free zirconium-89 ( 89 Zr, t1/2 : 78.4 h) labeling of manganese oxide NPs (Mn 3 O 4 @PEG) with ∼78\% labeling yield and good stability. Serial positron emission tomography (PET) and magnetic resonance imaging (MRI) studies non-invasively assessed the biodistribution patterns of the NPs and the feasibility of in vivo dual-modality imaging and lymph-node mapping. Since Mn 3 O 4 NPs exhibited desirable properties for enhanced T1 imaging and the simplicity of chelator-free radiolabeling, [ 89 Zr]Mn 3 O 4 @PEG NPs offer a novel, simple, safe and accurate nanoplatforms for future precise cancer imaging and diagnosis. ",
keywords = "Chelator-free, Magnetic resonance imaging, Manganese oxide nanoparticles, Positron emission tomography, Zirconium-89",
author = "Yonghua Zhan and Ehlerding, \{Emily B.\} and Sixiang Shi and Graves, \{Stephen A.\} and Shreya Goel and Engle, \{Jonathan W.\} and Jimin Liang and Weibo Cai",
note = "Funding Information: The authors confirm that there are no known conflicts of interest associated with this publication. Funding sources had no involvement in study design; collection, analysis, and interpretation of data; writing of the report; and in the Figure8. Serum biochemistry ofIlPiv:e 2r0a3n.d56k.id2n4e1y.1f2un8c Otionn: Thud,ecisio 24 Mnatoy 2su01b8m it11th:1e6a:2rticle9 for publication. markers. Healthy BALB/c mice were inCtraovpeynroigushlty: Ainmjecetreicdan Scientific Publishers with Mn3O4@PEG (dose: 20 mg kg−1 , and sacrificed oDnedliavyer7ed by Ingenta andday14post-injection(n=3),thedifferencebetweenAST Acknowledgments: This work was supported, in incontrolandthetreatmentgroupon14dayswerestatisti- part, by the University of Wisconsin-Madison, the cally significant (p < 0.05). National Institutes of Health (NIBIB/NCI 1R01CA169365, 1R01CA205101, 1R01EB021336, T32GM008505, T32CA009206, and P30CA014520), the American Can-cer Society (125246-RSG-13-099-01-CCE), the National Natural Science Foundation of China under Grant Nos. 81227901, 81571725, 81530058, 81230033, 31371006, 61405149, 81660505 and 81627807, the Natural Science Basic Research Plan in Shaanxi Province of China under Grant No. 2017JM8057, and the Fundamental Research Funds for the Central Universities (JB171204). Publisher Copyright: Copyright {\textcopyright} 2018 American Scientific Publishers All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2018",
month = may,
day = "1",
doi = "10.1166/jbn.2018.2498",
language = "English",
volume = "14",
pages = "900--909",
journal = "Journal of Biomedical Nanotechnology",
issn = "1550-7033",
publisher = "American Scientific Publishers",
number = "5",
}
