Intramolecular Hydrogen Bonding-Based Topology Regulation of Two-Dimensional Covalent Organic Frameworks

Yongwu Peng, Chongzhi Zhu, Bo Chen, Zhicheng Zhang, Zhuangchai Lai, Xiao Zhang, Chaoliang Tan, Yu Han, Yihan Zhu, Hua Zhang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

83 Citations (Scopus)


Creating molecular networks with different topologies using identical molecular linkers is fundamentally important but requires precise chemistry control. Here, we propose an effective strategy to regulate the network topologies of two-dimensional (2D) covalent organic frameworks (COFs) through the conformational switching of molecular linkages. By simply altering the substituents of an identical molecular linker, the topology-selective synthesis of two highly crystalline 2D COFs can be readily achieved. Their distinct crystal structures are observed and determined by low-dose, high-resolution transmission electron microscopy imaging, indicating that the driving force for linkage conformation switching is intramolecular hydrogen bonding. Our strategy would greatly diversify the COF topologies and enable vast postsynthetic modifications such as boron complexation, endowing these structures with a unique optical property such as fluorescence turn on and aggregation-induced emission.

Original languageEnglish
Pages (from-to)13162-13169
Number of pages8
JournalJournal of the American Chemical Society
Issue number30
Publication statusPublished - 29 Jul 2020
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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