Intracranial recording in patients with aphasia using nanomaterial-based flexible electronics: Promises and challenges

In recent years, researchers have studied how nanotechnology could enhance neuroimaging techniques. The application of nanomaterial-based flexible electronics has the potential to advance conventional intracranial electroencephalography (iEEG) by utilising brain-compatible soft nanomaterials. The resultant technique has significantly high spatial and temporal resolution, both of which enhance the localisation of brain functions and the mapping of dynamic language processing. This review presents findings on aphasia, an impairment in language and communication, and discusses how different brain imaging techniques, including positron emission tomography, magnetic resonance imaging, and iEEG, have advanced our understanding of the neural networks underlying language and reading processing. We then outline the strengths and weaknesses of iEEG in studying human cognition and the development of intracranial recordings that use brain-compatible flexible electrodes. We close by discussing the potential advantages and challenges of future investigations adopting nanomaterial-based flexible electronics for intracranial recording in patients with aphasia.