Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

Wui Man Lau, Suk Yu Yau, Tatia M C Lee, Yick Pang Ching, Siu Wa Tang, Kwok Fai So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

17 Citations (Scopus)


Adult neurogenesjs in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests.
Original languageEnglish
Pages (from-to)371-377
Number of pages7
Issue number4
Publication statusPublished - 4 Mar 2009
Externally publishedYes


  • Hippocampus
  • Neurogenesis
  • Prepulse inhibition disruption
  • Propulse inhibition
  • Sensorimotor gating
  • Subventricular zone

ASJC Scopus subject areas

  • General Neuroscience


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