International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV): Content and implementation in daily routine practice

Karin Jordan, Richard Gralla, Franziska Jahn, Alexandros Molasiotis

Research output: Journal article publicationReview articleAcademic researchpeer-review

118 Citations (Scopus)


Over the past decades major improvements in the management of chemotherapy induced nausea and vomiting (CINV) were obtained. With the correct use of antiemetic drugs, CINV can be prevented in almost 70%, and even up to, 80% of patients. Treatment guidelines enable physicians to integrate the latest clinical research into their daily practice. The large volume of rapidly evolving clinical data has been summarised and incorporated into treatment recommendations by well-known and reliable institutions. These organisations include the Multinational Association of Supportive Care in Cancer (MASCC), the European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), and National Comprehensive Cancer Network (NCCN). However, despite the availability of these guidelines, there is an emerging evidence that adherence to, and implementation of, treatment recommendations is less than optimal. This review will especially focus on the content of the current antiemetic guidelines and will address the important question of how these guidelines are implemented in routine practice.
Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - 5 Feb 2014


  • 5-HT serotonin receptor antagonists 3
  • Antiemetic therapy
  • ASCO antiemetic guidelines
  • MASCC/ESMO antiemetic guidelines
  • NCCN practice antiemesis guidelines
  • Neurokinin receptor antagonist 1

ASJC Scopus subject areas

  • Pharmacology

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