Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus

S. W. Choi, Iris Benzie, Siu Yin Lam, S. W.S. Chat, J. Lam, C. H. Yiu, J. J. Kwan, Y. H. Tang, G. S.P. Yeung, V. T.F. Yeung, G. C. Woo, B. M. Hannigan, J. J. Strain

Research output: Journal article publicationJournal articleAcademic researchpeer-review

38 Citations (Scopus)

Abstract

Aims: The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods: A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results: DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA1c(r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 μM, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions: The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.
Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalDiabetic Medicine
Volume22
Issue number10
DOIs
Publication statusPublished - 1 Oct 2005

Keywords

  • Antioxidants
  • Ascorbic acid
  • DNA damage
  • Glycaemic control
  • Vitamin C

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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