Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures

Chih Kuang Chen; Mong Chuan Lee; Zheng Ian Lin; Chun An Lee; Yu Chieh Tung; Ching Wen Lou; Wing Cheung Law; Nai Tzu Chen; Kun Yi Andrew Lin; Jia Horng Lin

doi:10.1021/acs.molpharmaceut.8b01011

Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures

Chih Kuang Chen, Mong Chuan Lee, Zheng Ian Lin, Chun An Lee, Yu Chieh Tung, Ching Wen Lou, Wing Cheung Law, Nai Tzu Chen, Kun Yi Andrew Lin, Jia Horng Lin

Research output: Journal article publication › Journal article › Academic research › peer-review

22 Citations (Scopus)

Abstract

Poly[2-(tert-butylaminoethyl) methacrylate] (PTA), an important class of antimicrobial polymers, has demonstrated its great biocidal efficiency, favorable nontoxicity, and versatile applicability. To further enhance its antimicrobial efficiency, an optimization of the chemical structure of PTA polymers is performed via atom transfer radical polymerization (ATRP) in terms of the antimicrobial ability against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After the optimization, the resulting PTA is blended into a polylactide (PLA) matrix to form PTA/PLA composite thin films. It is first found, that the antimicrobial efficiency of PTA/PLA composites was significantly enhanced by controlling the PLA crystallinity and the PLA spherulite size. A possible mechanistic route regarding this new finding has been rationally discussed. Lastly, the cytotoxicity and mechanical properties of a PTA/PLA composite thin film exhibiting the best biocidal effect are evaluated for assessing its potential as a new material for creating antimicrobial biomedical devices.

Original language	English
Pages (from-to)	709-723
Number of pages	15
Journal	Molecular Pharmaceutics
Volume	16
Issue number	2
DOIs	https://doi.org/10.1021/acs.molpharmaceut.8b01011
Publication status	Published - 4 Feb 2019

Keywords

antimicrobial composites
atom transfer radical polymerization
heat treatment
polylactide
poly[2-(tert-butylamino)ethyl methacrylate]

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

More information

10.1021/acs.molpharmaceut.8b01011

http://hdl.handle.net/10397/104454

Cite this

Chen, C. K., Lee, M. C., Lin, Z. I., Lee, C. A., Tung, Y. C., Lou, C. W., Law, W. C., Chen, N. T., Lin, K. Y. A., & Lin, J. H. (2019). Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures. Molecular Pharmaceutics, 16(2), 709-723. https://doi.org/10.1021/acs.molpharmaceut.8b01011

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abstract = "Poly[2-(tert-butylaminoethyl) methacrylate] (PTA), an important class of antimicrobial polymers, has demonstrated its great biocidal efficiency, favorable nontoxicity, and versatile applicability. To further enhance its antimicrobial efficiency, an optimization of the chemical structure of PTA polymers is performed via atom transfer radical polymerization (ATRP) in terms of the antimicrobial ability against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After the optimization, the resulting PTA is blended into a polylactide (PLA) matrix to form PTA/PLA composite thin films. It is first found, that the antimicrobial efficiency of PTA/PLA composites was significantly enhanced by controlling the PLA crystallinity and the PLA spherulite size. A possible mechanistic route regarding this new finding has been rationally discussed. Lastly, the cytotoxicity and mechanical properties of a PTA/PLA composite thin film exhibiting the best biocidal effect are evaluated for assessing its potential as a new material for creating antimicrobial biomedical devices.",

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Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures. / Chen, Chih Kuang; Lee, Mong Chuan; Lin, Zheng Ian et al.
In: Molecular Pharmaceutics, Vol. 16, No. 2, 04.02.2019, p. 709-723.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Lin, Zheng Ian

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AU - Tung, Yu Chieh

AU - Lou, Ching Wen

AU - Law, Wing Cheung

AU - Chen, Nai Tzu

AU - Lin, Kun Yi Andrew

AU - Lin, Jia Horng

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AB - Poly[2-(tert-butylaminoethyl) methacrylate] (PTA), an important class of antimicrobial polymers, has demonstrated its great biocidal efficiency, favorable nontoxicity, and versatile applicability. To further enhance its antimicrobial efficiency, an optimization of the chemical structure of PTA polymers is performed via atom transfer radical polymerization (ATRP) in terms of the antimicrobial ability against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After the optimization, the resulting PTA is blended into a polylactide (PLA) matrix to form PTA/PLA composite thin films. It is first found, that the antimicrobial efficiency of PTA/PLA composites was significantly enhanced by controlling the PLA crystallinity and the PLA spherulite size. A possible mechanistic route regarding this new finding has been rationally discussed. Lastly, the cytotoxicity and mechanical properties of a PTA/PLA composite thin film exhibiting the best biocidal effect are evaluated for assessing its potential as a new material for creating antimicrobial biomedical devices.

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Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures

Abstract

Keywords

ASJC Scopus subject areas

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