Intensifying the Antimicrobial Activity of Poly[2-(tert-butylamino)ethyl Methacrylate]/Polylactide Composites by Tailoring Their Chemical and Physical Structures

Chih Kuang Chen, Mong Chuan Lee, Zheng Ian Lin, Chun An Lee, Yu Chieh Tung, Ching Wen Lou, Wing Cheung Law, Nai Tzu Chen, Kun Yi Andrew Lin, Jia Horng Lin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)


Poly[2-(tert-butylaminoethyl) methacrylate] (PTA), an important class of antimicrobial polymers, has demonstrated its great biocidal efficiency, favorable nontoxicity, and versatile applicability. To further enhance its antimicrobial efficiency, an optimization of the chemical structure of PTA polymers is performed via atom transfer radical polymerization (ATRP) in terms of the antimicrobial ability against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After the optimization, the resulting PTA is blended into a polylactide (PLA) matrix to form PTA/PLA composite thin films. It is first found, that the antimicrobial efficiency of PTA/PLA composites was significantly enhanced by controlling the PLA crystallinity and the PLA spherulite size. A possible mechanistic route regarding this new finding has been rationally discussed. Lastly, the cytotoxicity and mechanical properties of a PTA/PLA composite thin film exhibiting the best biocidal effect are evaluated for assessing its potential as a new material for creating antimicrobial biomedical devices.

Original languageEnglish
Pages (from-to)709-723
Number of pages15
JournalMolecular Pharmaceutics
Issue number2
Publication statusPublished - 4 Feb 2019


  • antimicrobial composites
  • atom transfer radical polymerization
  • heat treatment
  • polylactide
  • poly[2-(tert-butylamino)ethyl methacrylate]

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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