TY - JOUR
T1 - Injectable, Self-Contained, Subaqueously Cross-Linking Laminous Adhesives for Biophysical-Chemical Modulation of Osteochondral Microenvironment
AU - Xu, Tianpeng
AU - Yang, Yuhe
AU - Yeung, Elton Hau Lam
AU - Chen, Qunchao
AU - Bei, Ho Pan
AU - Yang, Qiang
AU - Yang, Mo
AU - Hao, Yuefeng
AU - Li, Bin
AU - Zhao, Xin
N1 - Funding Information:
T.X. and Y.Y. contributed equally to this work. This work was supported by the Excellent Young Scholars Projects from National Science Foundation of China (82122002), Innovation and Technology Fund from Innovation and Technology Commission of Hong Kong (ITS/085/21 and GHP/032/20SZ), Young Scientist Fund of the National Science Foundation of China (8220293), Collaborative Research Equipment Grant (CREG) from Research Grants Council of Hong Kong (C5078‐21EF).
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023/6/2
Y1 - 2023/6/2
N2 - Current osteochondral (OC) defect repair approaches using premade scaffolds face clinical limitations due to invasiveness, weak integrity, and/or insufficient interfacial bonding. An injectable hydrophobic laminous adhesive is developed that rapidly photocross-link subaqueously and forms robust bi-layered structure that orchestrates biophysical-chemical cues for stimulating OC repair. Liquid hydrophobic photo-cross-linkable poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PmLnDMA) are adopted as cartilage phase and PmLnDMA encapsulating methacrylated hydroxyapatite nanoparticles (PmLnDMA/MH) as the mineralized subchondral bone phase. Both phases exhibit strong interfacial bonding due to the presence of “C-C”. Mechanotransduction and growth factor-mediated signaling pathways are enchanced by matching the mechanical properties of two phases to native cartilage and bone via systematical modulation of the adhesives’ composition and encapsulated growth factors’ release profile. This enhances mesenchymal stem cells’ commitment to corresponding chondrocytes and osteoblasts to augment OC repair in vitro and in vivo, and ultimately benefits patients suffering from OC fracture, osteoarthritis, and osteoporosis.
AB - Current osteochondral (OC) defect repair approaches using premade scaffolds face clinical limitations due to invasiveness, weak integrity, and/or insufficient interfacial bonding. An injectable hydrophobic laminous adhesive is developed that rapidly photocross-link subaqueously and forms robust bi-layered structure that orchestrates biophysical-chemical cues for stimulating OC repair. Liquid hydrophobic photo-cross-linkable poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PmLnDMA) are adopted as cartilage phase and PmLnDMA encapsulating methacrylated hydroxyapatite nanoparticles (PmLnDMA/MH) as the mineralized subchondral bone phase. Both phases exhibit strong interfacial bonding due to the presence of “C-C”. Mechanotransduction and growth factor-mediated signaling pathways are enchanced by matching the mechanical properties of two phases to native cartilage and bone via systematical modulation of the adhesives’ composition and encapsulated growth factors’ release profile. This enhances mesenchymal stem cells’ commitment to corresponding chondrocytes and osteoblasts to augment OC repair in vitro and in vivo, and ultimately benefits patients suffering from OC fracture, osteoarthritis, and osteoporosis.
KW - cell microenvironments
KW - injectable adhesives
KW - osteochondral regeneration
KW - subaqueous cross-linking
UR - http://www.scopus.com/inward/record.url?scp=85150764828&partnerID=8YFLogxK
U2 - 10.1002/adfm.202213428
DO - 10.1002/adfm.202213428
M3 - Journal article
AN - SCOPUS:85150764828
SN - 1616-301X
VL - 33
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 23
M1 - 2213428
ER -