Influence of intraocular and blood pressure on brain volumes: Observational and Mendelian randomization analyses

Xianwen Shang, Yu Huang (Corresponding Author), Susan Zhu, Zhuoting Zhu, Xueli Zhang, Wei Wang, Xiayin Zhang, Jing Liu, Jiahao Liu, Shulin Tang, Zongyuan Ge, Yijun Hu, Honghua Yu (Corresponding Author), Xiaohong Yang, Mingguang He (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Intraocular pressure (IOP) is closely correlated with blood pressure (BP), and while BP has been linked to brain volumes, the effect of IOP on brain volumes remains unclear. This study analyzed participants from the UK Biobank with MRI-measured brain volumes. Observational analyses included 8,634 participants for IOP and 36,069 for BP, followed by Mendelian randomization (MR) analyses of 37,410 participants. Observational analyses revealed that each 10-mmHg increase in diastolic BP was linked to a 0.13 mL larger white matter hyperintensity (WMH) after adjusting for covariates. Associations between IOP and brain volumes were more pronounced in younger individuals or those without hypertension. MR analyses confirmed significant relationships between diastolic BP and WMH, and each 5-mmHg increase in IOP reduced gray matter volumes by 3.24 mL. The study suggests that targeting IOP and BP could help prevent brain volume reduction.
Original languageEnglish
Article number110817
Pages (from-to)1-18
Number of pages19
JournaliScience
Volume27
Issue number11
DOIs
Publication statusE-pub ahead of print - 15 Nov 2024

Keywords

  • Bioinformatics
  • Cardiovascular medicine
  • Neuroscience

ASJC Scopus subject areas

  • General

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