Influence of geometry and environmental parameters on the quality of signature patterns for single neuron chemical sensors

The influence of geometry and environmental parameters on the quality of spectral finger print of single neurons to chemical agents patterned over planar microelectrode arrays is studied. Long-term studies of SNRs at individual electrodes are also explored. Upon the non-invasive conditions of chemical sensing, a remarkably stable recording environment is obtained. Analysis of the sources of noise from single neuron coupling to planar microelectrode array shows that, in the low frequency range, 1/f noise is the main source of the noise and in the high frequency range the Johnson noise plays a more dominant role. Optimal geometry factors and a better sealing condition of the microchamber environment lead to an increase in the signal-to-noise ratio (SNR) of the spectra. SNR measurements for ethanol sensing after denoising and comparison of the denosing results for a range of geometry factors and environmental conditions are demonstrated.