Influence of geometry and environmental parameters on the quality of signature patterns for single neuron chemical sensors

Mo Yang, Xuan Zhang, Cengiz S. Ozkan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)


The influence of geometry and environmental parameters on the quality of spectral finger print of single neurons to chemical agents patterned over planar microelectrode arrays is studied. Long-term studies of SNRs at individual electrodes are also explored. Upon the non-invasive conditions of chemical sensing, a remarkably stable recording environment is obtained. Analysis of the sources of noise from single neuron coupling to planar microelectrode array shows that, in the low frequency range, 1/f noise is the main source of the noise and in the high frequency range the Johnson noise plays a more dominant role. Optimal geometry factors and a better sealing condition of the microchamber environment lead to an increase in the signal-to-noise ratio (SNR) of the spectra. SNR measurements for ethanol sensing after denoising and comparison of the denosing results for a range of geometry factors and environmental conditions are demonstrated.
Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalSensors and Actuators, B: Chemical
Issue number1
Publication statusPublished - 3 Jan 2005
Externally publishedYes


  • Bioelectronic noise
  • Cell-based biosensors
  • Extracellular signal

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry
  • Electrical and Electronic Engineering

Cite this