Influence of autophagy on the efficacy of radiotherapy

Shing Yau Tam, Wing Cheung Vincent Wu, Ka Wai Helen Law

Research output: Journal article publicationReview articleAcademic researchpeer-review

39 Citations (Scopus)

Abstract

Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.
Original languageEnglish
Article number57
JournalRadiation Oncology
Volume12
Issue number1
DOIs
Publication statusPublished - 21 Mar 2017

Keywords

  • Autophagy
  • Cancer Cell lines
  • Radiosensitivity
  • Radiotherapy
  • Radiotherapy efficacy
  • Signalling pathway

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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