Influence of autophagy on the efficacy of radiotherapy

Shing Yau Tam; Wing Cheung Vincent Wu; Ka Wai Helen Law

doi:10.1186/s13014-017-0795-y

Influence of autophagy on the efficacy of radiotherapy

Shing Yau Tam, Wing Cheung Vincent Wu, Ka Wai Helen Law

Research output: Journal article publication › Review article › Academic research › peer-review

82 Citations (Scopus)

Abstract

Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.

Original language	English
Article number	57
Journal	Radiation Oncology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/s13014-017-0795-y
Publication status	Published - 21 Mar 2017

Keywords

Autophagy
Cancer Cell lines
Radiosensitivity
Radiotherapy
Radiotherapy efficacy
Signalling pathway

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1186/s13014-017-0795-y

http://hdl.handle.net/10397/70851

Cite this

@article{0886b7565fcf49e6b280754f5d1a7633,

title = "Influence of autophagy on the efficacy of radiotherapy",

abstract = "Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.",

keywords = "Autophagy, Cancer Cell lines, Radiosensitivity, Radiotherapy, Radiotherapy efficacy, Signalling pathway",

author = "Tam, {Shing Yau} and Wu, {Wing Cheung Vincent} and Law, {Ka Wai Helen}",

year = "2017",

month = mar,

day = "21",

doi = "10.1186/s13014-017-0795-y",

language = "English",

volume = "12",

journal = "Radiation Oncology",

issn = "1748-717X",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Influence of autophagy on the efficacy of radiotherapy

AU - Tam, Shing Yau

AU - Wu, Wing Cheung Vincent

AU - Law, Ka Wai Helen

PY - 2017/3/21

Y1 - 2017/3/21

N2 - Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.

AB - Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.

KW - Autophagy

KW - Cancer Cell lines

KW - Radiosensitivity

KW - Radiotherapy

KW - Radiotherapy efficacy

KW - Signalling pathway

UR - http://www.scopus.com/inward/record.url?scp=85015815244&partnerID=8YFLogxK

U2 - 10.1186/s13014-017-0795-y

DO - 10.1186/s13014-017-0795-y

M3 - Review article

C2 - 28320471

SN - 1748-717X

VL - 12

JO - Radiation Oncology

JF - Radiation Oncology

IS - 1

M1 - 57

ER -

Influence of autophagy on the efficacy of radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

More information

Other files and links

Fingerprint

Cite this