IncFII conjugative plasmid-mediated transmission of blaNDM-1elements among animal-borne Escherichia coli strains

Dachuan Lin, Miaomiao Xie, Ruichao Li, Kaichao Chen, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)


This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1in these strains. The blaNDM-1gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.
Original languageEnglish
Article numbere02285
JournalAntimicrobial Agents and Chemotherapy
Issue number1
Publication statusPublished - 1 Jan 2017


  • Animal
  • bla NDM-1
  • Escherichia coli
  • IncFII
  • Plasmid sequence
  • Transposons

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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