IncFII conjugative plasmid-mediated transmission of blaNDM-1elements among animal-borne Escherichia coli strains

Dachuan Lin; Miaomiao Xie; Ruichao Li; Kaichao Chen; Edward Wai Chi Chan; Sheng Chen

doi:10.1128/AAC.02285-16

IncFII conjugative plasmid-mediated transmission of bla_NDM-1elements among animal-borne Escherichia coli strains

Dachuan Lin, Miaomiao Xie, Ruichao Li, Kaichao Chen, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

20 Citations (Scopus)

Abstract

This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1in these strains. The blaNDM-1gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.

Original language	English
Article number	e02285
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	1
DOIs	https://doi.org/10.1128/AAC.02285-16
Publication status	Published - 1 Jan 2017

Keywords

Animal
bla NDM-1
Escherichia coli
IncFII
Plasmid sequence
Transposons

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1128/AAC.02285-16

Cite this

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abstract = "This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1in these strains. The blaNDM-1gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.",

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AU - Chen, Kaichao

AU - Chan, Edward Wai Chi

AU - Chen, Sheng

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AB - This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1in these strains. The blaNDM-1gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.

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KW - bla NDM-1

KW - Escherichia coli

KW - IncFII

KW - Plasmid sequence

KW - Transposons

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