IncFII conjugative plasmid-mediated transmission of blaNDM-1elements among animal-borne Escherichia coli strains

Dachuan Lin, Miaomiao Xie, Ruichao Li, Kaichao Chen, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1in these strains. The blaNDM-1gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.
Original languageEnglish
Article numbere02285
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Animal
  • bla NDM-1
  • Escherichia coli
  • IncFII
  • Plasmid sequence
  • Transposons

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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