In vivo tumor vasculature targeting of CuS@MSN based theranostic nanomedicine

Feng Chen, Hao Hong, Shreya Goel, Stephen A. Graves, Hakan Orbay, Emily B. Ehlerding, Sixiang Shi, Charles P. Theuer, Robert J. Nickles, Weibo Cai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

124 Citations (Scopus)

Abstract

Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.

Original languageEnglish
Pages (from-to)3926-3934
Number of pages9
JournalACS Nano
Volume9
Issue number4
DOIs
Publication statusPublished - 8 Apr 2015
Externally publishedYes

Keywords

  • CuS
  • mesoporous silica nanoparticle
  • photothermal ablation
  • theranostic nanomedicine
  • vasculature targeting

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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