In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Sixiang Shi; Feng Chen; Shreya Goel; Stephen A. Graves; Haiming Luo; Charles P. Theuer; Jonathan W. Engle; Weibo Cai

doi:10.1007/s40820-018-0216-2

In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Sixiang Shi, Feng Chen, Shreya Goel, Stephen A. Graves, Haiming Luo, Charles P. Theuer, Jonathan W. Engle, Weibo Cai

Research output: Journal article publication › Journal article › Academic research › peer-review

36 Citations (Scopus)

Abstract

Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem ⁶⁴Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.

Original language	English
Article number	65
Journal	Nano-Micro Letters
Volume	10
Issue number	4
Early online date	16 Jul 2018
DOIs	https://doi.org/10.1007/s40820-018-0216-2
Publication status	Published - 2018
Externally published	Yes

Keywords

CD105/endoglin
Hollow mesoporous silica nanoparticle (HMSN)
Molecular imaging
Optical imaging
Positron emission tomography (PET)
Quantum dot (QD)

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40820-018-0216-2

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title = "In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem",

abstract = "Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem 64Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.",

keywords = "CD105/endoglin, Hollow mesoporous silica nanoparticle (HMSN), Molecular imaging, Optical imaging, Positron emission tomography (PET), Quantum dot (QD)",

author = "Sixiang Shi and Feng Chen and Shreya Goel and Graves, {Stephen A.} and Haiming Luo and Theuer, {Charles P.} and Engle, {Jonathan W.} and Weibo Cai",

note = "Funding Information: Acknowledgements This work was supported, in part, by the University of Wisconsin–Madison, the National Institutes of Health (P30CA014520 and T32CA009206), and the American Cancer Society (125246-RSG-13-099-01-CCE). Publisher Copyright: {\textcopyright} 2018, The Author(s). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2018",

doi = "10.1007/s40820-018-0216-2",

language = "English",

volume = "10",

journal = "Nano-Micro Letters",

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AU - Shi, Sixiang

AU - Chen, Feng

AU - Goel, Shreya

AU - Graves, Stephen A.

AU - Luo, Haiming

AU - Theuer, Charles P.

AU - Engle, Jonathan W.

AU - Cai, Weibo

N1 - Funding Information: Acknowledgements This work was supported, in part, by the University of Wisconsin–Madison, the National Institutes of Health (P30CA014520 and T32CA009206), and the American Cancer Society (125246-RSG-13-099-01-CCE). Publisher Copyright: © 2018, The Author(s). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2018

Y1 - 2018

N2 - Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem 64Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.

AB - Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem 64Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.

KW - CD105/endoglin

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KW - Optical imaging

KW - Positron emission tomography (PET)

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In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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