In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Sixiang Shi, Feng Chen, Shreya Goel, Stephen A. Graves, Haiming Luo, Charles P. Theuer, Jonathan W. Engle, Weibo Cai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

29 Citations (Scopus)


Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem 64Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.

Original languageEnglish
Article number65
JournalNano-Micro Letters
Issue number4
Early online date16 Jul 2018
Publication statusPublished - 2018
Externally publishedYes


  • CD105/endoglin
  • Hollow mesoporous silica nanoparticle (HMSN)
  • Molecular imaging
  • Optical imaging
  • Positron emission tomography (PET)
  • Quantum dot (QD)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering


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