In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops

Kwok Ho Lui; Shiying Li; Wai Sum Lo; Yanjuan Gu; Wing Tak Wong

doi:10.1364/BOE.423982

In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops

Kwok Ho Lui, Shiying Li, Wai Sum Lo, Yanjuan Gu, Wing Tak Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

6 Citations (Scopus)

Abstract

Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO₂) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO₂ level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO₂ quantification.

Original language	English
Pages (from-to)	3597-3606
Number of pages	10
Journal	Biomedical Optics Express
Volume	12
Issue number	6
DOIs	https://doi.org/10.1364/BOE.423982
Publication status	Published - 1 Jun 2021

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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10.1364/BOE.423982

http://hdl.handle.net/10397/91373

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title = "In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops",

abstract = "Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO2) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO2 level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO2 quantification.",

author = "Lui, {Kwok Ho} and Shiying Li and Lo, {Wai Sum} and Yanjuan Gu and Wong, {Wing Tak}",

note = "Publisher Copyright: {\textcopyright} 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.",

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AU - Lui, Kwok Ho

AU - Li, Shiying

AU - Lo, Wai Sum

AU - Gu, Yanjuan

AU - Wong, Wing Tak

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO2) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO2 level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO2 quantification.

AB - Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO2) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO2 level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO2 quantification.

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In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops

Abstract

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