In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops

Kwok Ho Lui, Shiying Li, Wai Sum Lo, Yanjuan Gu, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO2) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO2 level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO2 quantification.

Original languageEnglish
Pages (from-to)3597-3606
Number of pages10
JournalBiomedical Optics Express
Volume12
Issue number6
DOIs
Publication statusPublished - 1 Jun 2021

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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