In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second

Zhihua Xie, Chengyou Shu, Daya Yang, Hao Chen, Chaobin Chen, Gang Dai, Kwok Ho Lam, Jinke Zhang, Xiatian Wang, Zonghai Sheng, Duyang Gao, Chengbo Liu, Liang Song, Xiaojing Gong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)


Intravascular photoacoustic (IVPA) imaging technology enables the visualization of pathological characteristics (such as inflammation activities, lipid deposition) of the artery wall. Blood flushing is a necessary step in improving the imaging quality in in vivo IVPA imaging. But the limited imaging speed of the systems stretches their flushing time, which is an important obstacle of their clinical translations. In this paper, we report an improvement in IVPA/IVUS imaging speed to 100 frames per second. The high-speed imaging is demonstrated in rabbit in vivo, visualizing the nanoparticles accumulated on abdominal aorta wall at the wavelength of 1064 nm, in real time display. Blood flushing in vivo improves the IVPA signal-noise-ratio by around 3.5 dB. This study offers a stable, efficient and easy-to-use tool for instantaneous disease visualization and disease diagnosis in research and forwards IVPA/IVUS imaging technology towards clinical translations.

Original languageEnglish
Pages (from-to)6721-6731
Number of pages11
JournalBiomedical Optics Express
Issue number11
Publication statusPublished - 1 Nov 2020

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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