In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Zhinxin Zhao; Roberto Gambari; Kenneth Ka Ho Lee; Stanton Hon Lung Kok; Raymond Siu Ming Wong; Fung Yi Lau; Cheuk On Tang; Kim Hung Lam; Chor Hing Cheng; Desmond Kwok Po Hau; Chung Hin Chui; Wai Yeung Wong; Wai Kwok Wong

doi:10.1016/j.bmcl.2013.02.049

In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Zhinxin Zhao, Roberto Gambari, Kenneth Ka Ho Lee, Stanton Hon Lung Kok, Raymond Siu Ming Wong, Fung Yi Lau, Cheuk On Tang, Kim Hung Lam, Chor Hing Cheng, Desmond Kwok Po Hau, Chung Hin Chui, Wai Yeung Wong, Wai Kwok Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

5 Citations (Scopus)

Abstract

We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.

Original language	English
Pages (from-to)	2373-2376
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.049
Publication status	Published - 15 Apr 2013

Keywords

Amphiphilic silicon(IV) phthalocyanine
Anticancer drugs
Hep3B
Nude mice xenograft
Rhodamine B
Toxicity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

More information

10.1016/j.bmcl.2013.02.049

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Zhao, Z., Gambari, R., Lee, K. K. H., Kok, S. H. L., Wong, R. S. M., Lau, F. Y., Tang, C. O., Lam, K. H., Cheng, C. H., Hau, D. K. P., Chui, C. H., Wong, W. Y., & Wong, W. K. (2013). In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B. Bioorganic and Medicinal Chemistry Letters, 23(8), 2373-2376. https://doi.org/10.1016/j.bmcl.2013.02.049

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abstract = "We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.",

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AU - Zhao, Zhinxin

AU - Gambari, Roberto

AU - Lee, Kenneth Ka Ho

AU - Kok, Stanton Hon Lung

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Tang, Cheuk On

AU - Lam, Kim Hung

AU - Cheng, Chor Hing

AU - Hau, Desmond Kwok Po

AU - Chui, Chung Hin

AU - Wong, Wai Yeung

AU - Wong, Wai Kwok

PY - 2013/4/15

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AB - We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.

KW - Amphiphilic silicon(IV) phthalocyanine

KW - Anticancer drugs

KW - Hep3B

KW - Nude mice xenograft

KW - Rhodamine B

KW - Toxicity

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M3 - Journal article

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SN - 0960-894X

VL - 23

SP - 2373

EP - 2376

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Abstract

Keywords

ASJC Scopus subject areas

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