In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B

Zhinxin Zhao, Roberto Gambari, Kenneth Ka Ho Lee, Stanton Hon Lung Kok, Raymond Siu Ming Wong, Fung Yi Lau, Cheuk On Tang, Kim Hung Lam, Chor Hing Cheng, Desmond Kwok Po Hau, Chung Hin Chui, Wai Yeung Wong, Wai Kwok Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)

Abstract

We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.
Original languageEnglish
Pages (from-to)2373-2376
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number8
DOIs
Publication statusPublished - 15 Apr 2013

Keywords

  • Amphiphilic silicon(IV) phthalocyanine
  • Anticancer drugs
  • Hep3B
  • Nude mice xenograft
  • Rhodamine B
  • Toxicity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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