In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma

Desmond Kwok Po Hau; Guo Yuan Zhu; Alexander Kai Man Leung; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Paul Bo San Lai; Sze Wai Tong; Fung Yi Lau; Kit Wah Chan; Wai Yeung Wong; Kim Hung Lam; Chor Hing Cheng; Filly Cheung; Chung Hin Chui; Roberto Gambari; David Wang Fun Fong

doi:10.1016/j.phymed.2010.09.001

In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma

Desmond Kwok Po Hau, Guo Yuan Zhu, Alexander Kai Man Leung, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Paul Bo San Lai, Sze Wai Tong, Fung Yi Lau, Kit Wah Chan, Wai Yeung Wong, Kim Hung Lam, Chor Hing Cheng, Filly Cheung, Chung Hin Chui, Roberto Gambari, David Wang Fun Fong

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

50 Citations (Scopus)

Abstract

We have investigated the potential in vivo anti-tumour activity of corilagin using the Hep3B hepatocellular carcinoma cell line and an athymic nude mice xenograft model. The purity of corilagin was confirmed by high performance liquid chromatographic analysis. Corilagin was administrated intraperitoneally for a continuous period of 7 days at a concentration of 15. mg/kg of body weight per day. A significant inhibition of tumour growth was observed when treated mice are compared with control groups. Furthermore, analysis of enzymes markers of liver function, including alanine aminotransferase and asparate aminotransferase, suggested that current therapeutic dosage of corilagin did not exert adverse effect on liver. Our observations support the view that corilagin is considerably effective to retard the in vivo growth of xenografted Hep3B hepatocellular carcinoma.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	Phytomedicine
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.phymed.2010.09.001
Publication status	Published - 15 Dec 2010

Keywords

Corilagin
Hepatocellular carcinoma
Xenograft model

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1016/j.phymed.2010.09.001

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Hau, D. K. P., Zhu, G. Y., Leung, A. K. M., Wong, R. S. M., Cheng, G. Y. M., Lai, P. B. S., Tong, S. W., Lau, F. Y., Chan, K. W., Wong, W. Y., Lam, K. H., Cheng, C. H., Cheung, F., Chui, C. H., Gambari, R., & Fong, D. W. F. (2010). In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma. Phytomedicine, 18(1), 11-15. https://doi.org/10.1016/j.phymed.2010.09.001

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abstract = "We have investigated the potential in vivo anti-tumour activity of corilagin using the Hep3B hepatocellular carcinoma cell line and an athymic nude mice xenograft model. The purity of corilagin was confirmed by high performance liquid chromatographic analysis. Corilagin was administrated intraperitoneally for a continuous period of 7 days at a concentration of 15. mg/kg of body weight per day. A significant inhibition of tumour growth was observed when treated mice are compared with control groups. Furthermore, analysis of enzymes markers of liver function, including alanine aminotransferase and asparate aminotransferase, suggested that current therapeutic dosage of corilagin did not exert adverse effect on liver. Our observations support the view that corilagin is considerably effective to retard the in vivo growth of xenografted Hep3B hepatocellular carcinoma.",

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AU - Cheng, Gregory Yin Ming

AU - Lai, Paul Bo San

AU - Tong, Sze Wai

AU - Lau, Fung Yi

AU - Chan, Kit Wah

AU - Wong, Wai Yeung

AU - Lam, Kim Hung

AU - Cheng, Chor Hing

AU - Cheung, Filly

AU - Chui, Chung Hin

AU - Gambari, Roberto

AU - Fong, David Wang Fun

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In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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