In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Raymond Wai Yin Sun; Wing Yiu Yu; Hongzhe Sun; Chi Ming Che

doi:10.1002/cbic.200300773

In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Raymond Wai Yin Sun
, Wing Yiu Yu
, Hongzhe Sun
, Chi Ming Che

Research output: Journal article publication › Journal article › Academic research › peer-review

54 Citations (Scopus)

Abstract

A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

Original language	English
Pages (from-to)	1293-1298
Number of pages	6
Journal	ChemBioChem
Volume	5
Issue number	9
DOIs	https://doi.org/10.1002/cbic.200300773
Publication status	Published - 6 Sept 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gold
HIV
Macrocyclic ligands
Porphyrinoids
Reverse transcriptase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

More information

10.1002/cbic.200300773

Cite this

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title = "In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins",

abstract = "A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67\%) can be produced by the {"}1 a + AZT-TP{"} protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.",

keywords = "Gold, HIV, Macrocyclic ligands, Porphyrinoids, Reverse transcriptase",

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AU - Sun, Raymond Wai Yin

AU - Yu, Wing Yiu

AU - Sun, Hongzhe

AU - Che, Chi Ming

PY - 2004/9/6

Y1 - 2004/9/6

N2 - A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

AB - A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

KW - Gold

KW - HIV

KW - Macrocyclic ligands

KW - Porphyrinoids

KW - Reverse transcriptase

UR - https://www.scopus.com/pages/publications/4644297701

U2 - 10.1002/cbic.200300773

DO - 10.1002/cbic.200300773

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JO - ChemBioChem

JF - ChemBioChem

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ER -

In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

More information

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