In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Raymond Wai Yin Sun, Wing Yiu Yu, Hongzhe Sun, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

40 Citations (Scopus)

Abstract

A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.
Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalChemBioChem
Volume5
Issue number9
DOIs
Publication statusPublished - 6 Sep 2004
Externally publishedYes

Keywords

  • Gold
  • HIV
  • Macrocyclic ligands
  • Porphyrinoids
  • Reverse transcriptase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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