In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Raymond Wai Yin Sun; Wing Yiu Yu; Hongzhe Sun; Chi Ming Che

doi:10.1002/cbic.200300773

In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Raymond Wai Yin Sun, Wing Yiu Yu, Hongzhe Sun, Chi Ming Che

Research output: Journal article publication › Journal article › Academic research › peer-review

48 Citations (Scopus)

Abstract

A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

Original language	English
Pages (from-to)	1293-1298
Number of pages	6
Journal	ChemBioChem
Volume	5
Issue number	9
DOIs	https://doi.org/10.1002/cbic.200300773
Publication status	Published - 6 Sept 2004
Externally published	Yes

Keywords

Gold
HIV
Macrocyclic ligands
Porphyrinoids
Reverse transcriptase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cbic.200300773

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AU - Che, Chi Ming

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AB - A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

KW - Gold

KW - HIV

KW - Macrocyclic ligands

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KW - Reverse transcriptase

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In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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