In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine

Wenyi Wang; Patrick C.L. Hui; Elaine Wat; Frency S.F. Ng; Chi Wai Kan; Xiaowen Wang; Eric C.W. Wong; Huawen Hu; Ben Chan; Clara B.S. Lau; Ping Chung Leung

doi:10.1016/j.colsurfb.2016.09.036

In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine

Wenyi Wang, Patrick C.L. Hui, Elaine Wat, Frency S.F. Ng, Chi Wai Kan, Xiaowen Wang, Eric C.W. Wong, Huawen Hu, Ben Chan, Clara B.S. Lau, Ping Chung Leung

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

41 Citations (Scopus)

Abstract

For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.

Original language	English
Pages (from-to)	526-532
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	148
DOIs	https://doi.org/10.1016/j.colsurfb.2016.09.036
Publication status	Published - 1 Dec 2016

Keywords

Herbal medicine
Percutaneous behavior
Release kinetic
Thermosensitive hydrogel therapy

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

More information

10.1016/j.colsurfb.2016.09.036

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Wang, W., Hui, P. C. L., Wat, E., Ng, F. S. F., Kan, C. W., Wang, X., Wong, E. C. W., Hu, H., Chan, B., Lau, C. B. S., & Leung, P. C. (2016). In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine. Colloids and Surfaces B: Biointerfaces, 148, 526-532. https://doi.org/10.1016/j.colsurfb.2016.09.036

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abstract = "For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.",

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author = "Wenyi Wang and Hui, {Patrick C.L.} and Elaine Wat and Ng, {Frency S.F.} and Kan, {Chi Wai} and Xiaowen Wang and Wong, {Eric C.W.} and Huawen Hu and Ben Chan and Lau, {Clara B.S.} and Leung, {Ping Chung}",

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doi = "10.1016/j.colsurfb.2016.09.036",

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AU - Wang, Wenyi

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AU - Wat, Elaine

AU - Ng, Frency S.F.

AU - Kan, Chi Wai

AU - Wang, Xiaowen

AU - Wong, Eric C.W.

AU - Hu, Huawen

AU - Chan, Ben

AU - Lau, Clara B.S.

AU - Leung, Ping Chung

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N2 - For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.

AB - For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.

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KW - Percutaneous behavior

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SN - 0927-7765

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In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine

Abstract

Keywords

ASJC Scopus subject areas

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