In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine

Wenyi Wang, Chi Leung Hui, Elaine Wat, Frency S.F. Ng, Chi Wai Kan, Xiaowen Wang, Eric C.W. Wong, Huawen Hu, Ben Chan, Clara B.S. Lau, Ping Chung Leung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

20 Citations (Scopus)

Abstract

This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.
Original languageEnglish
Pages (from-to)526-532
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume148
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Herbal medicine
  • Percutaneous behavior
  • Release kinetic
  • Thermosensitive hydrogel therapy

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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