In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

Xinghou Gong; Chak Yin Tang; Ling Pan; Zhonghua Hao; Chi Pong Tsui; Jianing Liu

doi:10.1016/j.compositesb.2013.06.034

In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

Xinghou Gong, Chak Yin Tang, Ling Pan, Zhonghua Hao, Chi Pong Tsui, Jianing Liu

Research output: Journal article publication › Journal article › Academic research › peer-review

15 Citations (Scopus)

Abstract

In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds.

Original language	English
Pages (from-to)	234-239
Number of pages	6
Journal	Composites Part B: Engineering
Volume	55
DOIs	https://doi.org/10.1016/j.compositesb.2013.06.034
Publication status	Published - 24 Jul 2013

Keywords

A. Nano-structures
A. Polymer-matrix composites (PMCs)
B. Optical properties/techniques
In vitro degradation

ASJC Scopus subject areas

Ceramics and Composites
Mechanics of Materials
Mechanical Engineering
Industrial and Manufacturing Engineering

More information

10.1016/j.compositesb.2013.06.034

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title = "In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds",

abstract = "In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds.",

keywords = "A. Nano-structures, A. Polymer-matrix composites (PMCs), B. Optical properties/techniques, In vitro degradation",

author = "Xinghou Gong and Tang, {Chak Yin} and Ling Pan and Zhonghua Hao and Tsui, {Chi Pong} and Jianing Liu",

year = "2013",

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day = "24",

doi = "10.1016/j.compositesb.2013.06.034",

language = "English",

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journal = "Composites Part B: Engineering",

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T1 - In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

AU - Gong, Xinghou

AU - Tang, Chak Yin

AU - Pan, Ling

AU - Hao, Zhonghua

AU - Tsui, Chi Pong

AU - Liu, Jianing

PY - 2013/7/24

Y1 - 2013/7/24

N2 - In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds.

AB - In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds.

KW - A. Nano-structures

KW - A. Polymer-matrix composites (PMCs)

KW - B. Optical properties/techniques

KW - In vitro degradation

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U2 - 10.1016/j.compositesb.2013.06.034

DO - 10.1016/j.compositesb.2013.06.034

M3 - Journal article

SN - 1359-8368

VL - 55

SP - 234

EP - 239

JO - Composites Part B: Engineering

JF - Composites Part B: Engineering

ER -

In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

Abstract

Keywords

ASJC Scopus subject areas

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