In vitro degradation and subsequent biomechanical changes of braided biodegradable conduits for peripheral nerve regeneration

Guo Hua Liu, Hong Hu, Pei Hua Zhang, Wen Zu Wang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

A new kind of the biodegradable poly (glycolide-co-lactide acid) (PGLA) conduits for peripheral nerve regeneration were produced by braiding technology and soaking process. The in vitro degradation was simulated by immerging the conduits in a phosphate buffer saline (PBS) solution with pH 7.4 at 37°C. The variations of the mass and radial compressive properties during in vitro degradation were investigated. The influences of the composition of the polymeric materials and the braided structures were discussed. The results have shown that conduits produced with triaxial braided structure and PGLA (90:10) have stable biomechanical performance with feasible degradation rate, which can be more effective for nerve regeneration and repair and may lead to clinical application.
Original languageEnglish
Title of host publication"New Century, New Materials and New Life" - Proceedings of 2005 International Conference on Advanced Fibers and Polymer Materials, ICAFPM 2005
PublisherChina Press
Pages979-982
Number of pages4
Volume2
ISBN (Print)7502577173, 9787502577179
Publication statusPublished - 1 Jan 2005
Externally publishedYes
Event2005 International Conference on Advanced Fibers and Polymer Materials, ICAFPM 2005 - Shanghai, China
Duration: 19 Oct 200521 Oct 2005

Conference

Conference2005 International Conference on Advanced Fibers and Polymer Materials, ICAFPM 2005
Country/TerritoryChina
CityShanghai
Period19/10/0521/10/05

ASJC Scopus subject areas

  • Polymers and Plastics
  • Biomaterials

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