In vitro and in vivo degradation evaluation of Mg-based alloys for biomedical applications

Biodegradable metals have attracted interest for implant applications because of the potential to eliminate secondary surgeries. Magnesium-based (Mg-based) alloys are potential candidates. The purpose of this study was to evaluate the in vitro and in vivo degradation performances of two custom-made magnesium-based alloys and to determine whether they are sustainable for further investigation. The performances of Magnesium-Zinc-Manganese (Mg-Zn-Mn) alloys at 5% and 1% zinc levels were compared using a mechanical test, hydrogen evolution test, cell viability (MTT) test, and a short term mice subcutaneous implantation. The results showed that the corrosion resistance of the Mg was improved by alloying. While Mg-5Zn-1Mn was more corrodible compared with Mg-1Zn-1Mn, neither of the alloys presented any adverse effects preliminarily and both were suitable for long-term testing for biomedical applications.