In vitro activity of posaconazole against Talaromyces marneffei by broth microdilution and Etest methods and comparison to itraconazole, voriconazole, and anidulafungin

Susanna K.P. Lau, George C.S. Lo, Clare S.K. Lam, Wang Ngai Chow, Antonio H.Y. Ngan, Alan K.L. Wu, Dominic N.C. Tsang, Cindy W.S. Tse, Tak Lun Que, Bone S.F. Tang, Patrick C.Y. Woo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

We determined the susceptibilities of 57 Talaromyces marneffei strains to anidulafungin, itraconazole, voriconazole, and posaconazole with MICs of 2 to 8, 0.002 to 0.004, 0.016 to 0.063, and 0.001 to 0.002 μg/ml by broth microdilution and >32, ≤0.002 to 0.008, ≤0.002 to 0.008, and ≤0.002 μg/ml by Etest, respectively, at yeast phase; MICs at mycelial phase for anidulafungin and posaconazole were 1 to 2 and 0.004 to 0.063 μg/ml, respectively. The results suggest promising activities of posaconazole. Etest can be used for testing of azoles against T. marneffei.

Original languageEnglish
Article numbere01480
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number3
Early online date23 Feb 2017
DOIs
Publication statusPublished - Mar 2017
Externally publishedYes

Keywords

  • Anidulafungin
  • Etest
  • Itraconazole
  • Penicillium
  • Posaconazole
  • Susceptibility
  • Talaromyces marneffei
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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