TY - JOUR
T1 - In utero exposure to gestational diabetes and adiposity
T2 - does breastfeeding make a difference?
AU - Hui, L. L.
AU - Li, A. M.
AU - Nelson, E. A.S.
AU - Leung, G. M.
AU - Lee, S. L.
AU - Schooling, C. M.
N1 - Funding Information:
Acknowledgements We thank colleagues at the Student Health Service and Family Health Service of the Department of Health for their assistance and collaboration. We also thank the late Dr. Connie O for coordinating the project and all the fieldwork for the initial study in 1997–1998. This work is a sub-study of the “Children of 1997” birth cohort which was initially supported by the Health Care and Promotion Fund, Health and Welfare Bureau, Government of the Hong Kong SAR [HCPF Grant # 216106] and re-established in 2005 with support from the Health and Health Services Research Fund [HHSRF Grant # 03040771], and the University Research Committee Strategic Research Theme (SRT) of Public Health, The University of Hong Kong. This sub-study builds on information added to the birth cohort by RFCID grant # 04050172 and HHSRF grant # 08090761, and was funded by the Health and Health Services Research Fund [HHSRF Grant # 12132731], Government of the Hong Kong SAR.
Funding Information:
The study was reviewed by and received approval from the University of Hong Kong, Hospital Authority Hong Kong West Cluster Joint Institutional Review Board and the Joint Chinese University of Hong Kong—New Territories East Cluster Clinical Research Ethics Committee. Informed consent was obtained from the parents/guardians whose child participated in the birth cohort “Children of 1997”.
Publisher Copyright:
© 2018, Macmillan Publishers Limited, part of Springer Nature.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Background/objectives: Short-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy. Methods: In the prospective Chinese birth cohort “Children of 1997” (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2– < 8 years) and adolescence (8–16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position. We also tested whether the associations differed by mode of infant feeding (always formula-fed, mixed, always breastfed) during the first three months of life. Results: In utero GDM exposure (7.5%) was associated with a lower BMI z-score during infancy (−0.13, 95% confidence interval (CI) −0.22, −0.05) but higher BMI z-scores during childhood (0.14, 95% CI 0.03, 0.25) and adolescence (0.25 95% CI 0.11, 0.38). Breastfeeding for the first three months did not modify the association of in utero GDM status with subsequent BMI (all p values for interaction >0.4). Conclusions: In utero GDM exposure was associated with greater adiposity during childhood and adolescence. Breastfeeding in early infancy from mothers with GDM was not associated with greater adiposity in children and thus should still be encouraged.
AB - Background/objectives: Short-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy. Methods: In the prospective Chinese birth cohort “Children of 1997” (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2– < 8 years) and adolescence (8–16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position. We also tested whether the associations differed by mode of infant feeding (always formula-fed, mixed, always breastfed) during the first three months of life. Results: In utero GDM exposure (7.5%) was associated with a lower BMI z-score during infancy (−0.13, 95% confidence interval (CI) −0.22, −0.05) but higher BMI z-scores during childhood (0.14, 95% CI 0.03, 0.25) and adolescence (0.25 95% CI 0.11, 0.38). Breastfeeding for the first three months did not modify the association of in utero GDM status with subsequent BMI (all p values for interaction >0.4). Conclusions: In utero GDM exposure was associated with greater adiposity during childhood and adolescence. Breastfeeding in early infancy from mothers with GDM was not associated with greater adiposity in children and thus should still be encouraged.
UR - https://www.scopus.com/pages/publications/85047122986
U2 - 10.1038/s41366-018-0077-2
DO - 10.1038/s41366-018-0077-2
M3 - Journal article
C2 - 29777227
AN - SCOPUS:85047122986
SN - 0307-0565
VL - 42
SP - 1317
EP - 1325
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 7
ER -
