In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells

Qi Lang, Yukun Ren, Divia Hobson, Ye Tao, Likai Hou, Yankai Jia, Qingming Hu, Jiangwei Liu, Xin Zhao, Hongyuan Jiang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

28 Citations (Scopus)

Abstract

� 2016 Author(s). Herein, we first describe a perfusion chip integrated with an AC electrothermal (ACET) micromixer to supply a uniform drug concentration to tumor cells. The in-plane fluid microvortices for mixing were generated by six pairs of reconstructed novel ACET asymmetric electrodes. To enhance the mixing efficiency, the novel ACET electrodes with rotating angles of 0�, 30�, and 60� were investigated. The asymmetric electrodes with a rotating angle of 60� exhibited the highest mixing efficiency by both simulated and experimental results. The length of the mixing area is 7 mm, and the mixing efficiency is 89.12% (approximate complete mixing) at a voltage of 3 V and a frequency of 500 kHz. The applicability of our micromixer with electrodes rotating at 60� was demonstrated by the drug (tamoxifen) test of human breast cancer cells (MCF-7) for five days, which implies that our ACET in-plane microvortices micromixer has great potential for the application of drug induced rapid death of tumor cells and mixing of biomaterials in organs-on-a-chip systems.
Original languageEnglish
Article number064102
JournalBiomicrofluidics
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Materials Science(all)
  • Genetics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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