Implementation and new insights in molecular diagnostics for HIV infection

Hin Fung Tsang, Lawrence Wing Chi Chan, Jennifer Chiu Hung Tong, Heong Ting Wong, Christopher Koon Chi Lai, Thomas Chi Chuen Au, Amanda Kit Ching Chan, Lawrence Po Wah Ng, William Chi Shing Cho, Sze Chuen Cesar Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

Introduction: Acquired immunodeficiency syndrome (AIDS) is a kind of acquired disease that breaks down the immune system. Human immunodeficiency virus (HIV) is the causative agent of AIDS. By the end of 2016, there were 36.7 million people living with HIV worldwide. Early diagnosis can alert infected individuals to risk behaviors in order to control HIV transmission. Infected individuals are also benefited from proper treatment and management upon early diagnosis. Thanks to the public awareness of the disease, the annual increase of new HIV infections has been slowly declining over the past decades. The advent of molecular diagnostics has allowed early detection and better management of HIV infected patients. Areas covered: In this review, the authors summarized and discussed the current and future technologies in molecular diagnosis as well as the biomarkers developed for HIV infection. Expert Commentary: A simple and rapid detection of viral load is important for patients and doctors to monitor HIV progression and antiretroviral treatment efficiency. In the near future, it is expected that new technologies such as digital PCR and CRISPR-based technology will play more important role in HIV detection and patient management.

Original languageEnglish
Pages (from-to)433-441
Number of pages9
JournalExpert Review of Molecular Diagnostics
Volume18
Issue number5
Early online date19 Apr 2018
DOIs
Publication statusPublished - May 2018

Keywords

  • Acquired immunodeficiency syndrome
  • AIDS
  • HIV detection
  • human immunodeficiency virus
  • molecular diagnostics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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