Immunologic and neurodevelopmental susceptibilities of autism

Isaac N. Pessah, Richard F. Seegal, Pamela J. Lein, Janine LaSalle, Kay Yan Benjamin Yee, Judy Van De Water, Robert F. Berman

Research output: Journal article publicationJournal articleAcademic researchpeer-review

41 Citations (Scopus)

Abstract

Symposium 5 focused on research approaches that are aimed at understanding common patterns of immunological and neurological dysfunction contributing to neurodevelopmental disorders such as autism and ADHD. The session focused on genetic, epigenetic, and environmental factors that might act in concert to influence autism risk, severity and co-morbidities, and immunological and neurobiological targets as etiologic contributors. The immune system of children at risk of autism may be therefore especially susceptible to psychological stressors, exposure to chemical triggers, and infectious agents. Identifying early biomarkers of risk provides tangible approaches toward designing studies in animals and humans that yield a better understanding of environmental risk factors, and can help identify rational intervention strategies to mitigate these risks.
Original languageEnglish
Pages (from-to)531-544
Number of pages14
JournalNeuroToxicology
Volume29
Issue number3
DOIs
Publication statusPublished - 1 May 2008
Externally publishedYes

Keywords

  • ADHD
  • Autism
  • Mercury
  • Neuroimmunology
  • Organochlorines
  • Organophosphate
  • Polychlorinated biphenyls

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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