Immobilization of engineered arginase on gold-carbon nanotubes

Gordon Kuen Chan Lee; Sui Yi Kwok; Chih Hao Yu; Kin Tam; Hiu Chi Chong; Yun Chung Leung; Shik Chi Edman Tsang

doi:10.1039/c2cc32863a

Immobilization of engineered arginase on gold-carbon nanotubes

Gordon Kuen Chan Lee
, Sui Yi Kwok
, Chih Hao Yu
, Kin Tam
, Hiu Chi Chong
, Yun Chung Leung
, Shik Chi Edman Tsang

Research output: Journal article publication › Journal article › Academic research › peer-review

6 Citations (Scopus)

Abstract

It is demonstrated that engineered arginase with a single protruded site of cysteine deliberately placed away from its active centre by site-directed mutagenesis can facilitate its attachment on a gold-nanoparticle surface with atomic precision, resulting in no apparent loss in enzymatic activity.

Original language	English
Pages (from-to)	7693-7695
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	62
DOIs	https://doi.org/10.1039/c2cc32863a
Publication status	Published - 11 Aug 2012

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc32863a

Cite this

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title = "Immobilization of engineered arginase on gold-carbon nanotubes",

abstract = "It is demonstrated that engineered arginase with a single protruded site of cysteine deliberately placed away from its active centre by site-directed mutagenesis can facilitate its attachment on a gold-nanoparticle surface with atomic precision, resulting in no apparent loss in enzymatic activity.",

author = "Lee, \{Gordon Kuen Chan\} and Kwok, \{Sui Yi\} and Yu, \{Chih Hao\} and Kin Tam and Chong, \{Hiu Chi\} and Leung, \{Yun Chung\} and Tsang, \{Shik Chi Edman\}",

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AU - Lee, Gordon Kuen Chan

AU - Kwok, Sui Yi

AU - Yu, Chih Hao

AU - Tam, Kin

AU - Chong, Hiu Chi

AU - Leung, Yun Chung

AU - Tsang, Shik Chi Edman

PY - 2012/8/11

Y1 - 2012/8/11

N2 - It is demonstrated that engineered arginase with a single protruded site of cysteine deliberately placed away from its active centre by site-directed mutagenesis can facilitate its attachment on a gold-nanoparticle surface with atomic precision, resulting in no apparent loss in enzymatic activity.

AB - It is demonstrated that engineered arginase with a single protruded site of cysteine deliberately placed away from its active centre by site-directed mutagenesis can facilitate its attachment on a gold-nanoparticle surface with atomic precision, resulting in no apparent loss in enzymatic activity.

UR - https://www.scopus.com/pages/publications/84863895581

U2 - 10.1039/c2cc32863a

DO - 10.1039/c2cc32863a

M3 - Journal article

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SN - 1359-7345

VL - 48

SP - 7693

EP - 7695

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

Immobilization of engineered arginase on gold-carbon nanotubes

Abstract

ASJC Scopus subject areas

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