IGF-IEc expression, regulation and biological function in different tissues

Zhongquan Dai, Feng Wu, Wai Ella Yeung, Yinghui Li

Research output: Journal article publicationReview articleAcademic researchpeer-review

55 Citations (Scopus)

Abstract

Insulin-like growth factor I (IGF-I) is an important growth factor for embryonic development, postnatal growth, tissue repair and maintenance of homeostasis. IGF-I functions and regulations are complex and tissue-specific. IGF-I mediates growth hormone signaling to target tissues during growth, but many IGF-I variants have been discovered, resulting in complex models to describe IGF-I function and regulation. Mechano-growth factor (MGF) is an alternative splicing variant of IGF-I and serves as a local tissue repair factor that responds to changes in physiological conditions or environmental stimuli. MGF expression is significantly increased in muscle, bone and tendon following damage resulting from mechanical stimuli and in the brain and heart following ischemia. MGF has been shown to activate satellite cells in muscle resulting in hypertrophy or regeneration, and functions as a neuroprotectant in brain ischemia. Both expression and processing of this IGF-I variant are tissue specific, but the functional mechanism is poorly understood. MGF and its short derivative have been examined as a potential therapy for muscular dystrophy and cerebral hypoxia-ischemia using experimental animals. Although the unique mode of action of MGF has been identified, the details remain elusive. Here we review the expression and regulation of MGF and the function of this IGF-I isoform in tissue protection.
Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalGrowth Hormone and IGF Research
Volume20
Issue number4
DOIs
Publication statusPublished - 1 Aug 2010

Keywords

  • Alternative splicing
  • IGF-I
  • Mechanical stimuli
  • MGF
  • Skeletal muscle
  • Tissue protection

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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