Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite

Ye Yang; Min Wang; Ting Ting Zhang; Yin Cai; Ran Bi; Chen Luo

Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite

Ye Yang, Min Wang, Ting Ting Zhang, Yin Cai, Ran Bi, Chen Luo

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

Aim: To identify the isolated strain from the soil sample obtained near the yellow sea beach and to investigate the antibacterial and antitumor activities of its secondary metabolite as well as its structural information. Methods: The 16s r DNA and morphological characteristics of the isolated strain were investigated. BSC, the secondary metabolite of the strain, was also studied for its antibacterial and antitumor activities, as well as its structure. Results: Based on the 16s rDNA and morphological features, this new strain was confirmed to be Bacillus sp., BSC effectively inhibited the growth of bacterial and tumor cells in vitro, and the molecular formula of BSC is C₄₈ H₉₄ O₁₉. Conclusion: The isolated strain belongs to Bacillus sp. BSC has fair antibacterial and antitumor activities, and it is one potential antibiotic.

Original language	English
Pages (from-to)	368-372
Number of pages	5
Journal	Journal of China Pharmaceutical University
Volume	39
Issue number	4
Publication status	Published - Aug 2008
Externally published	Yes

Keywords

Antibacterial
Antitumor
Bacillus sp.
Secondary metabolite
Structure analysis

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

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title = "Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite",

abstract = "Aim: To identify the isolated strain from the soil sample obtained near the yellow sea beach and to investigate the antibacterial and antitumor activities of its secondary metabolite as well as its structural information. Methods: The 16s r DNA and morphological characteristics of the isolated strain were investigated. BSC, the secondary metabolite of the strain, was also studied for its antibacterial and antitumor activities, as well as its structure. Results: Based on the 16s rDNA and morphological features, this new strain was confirmed to be Bacillus sp., BSC effectively inhibited the growth of bacterial and tumor cells in vitro, and the molecular formula of BSC is C48 H94 O19. Conclusion: The isolated strain belongs to Bacillus sp. BSC has fair antibacterial and antitumor activities, and it is one potential antibiotic.",

keywords = "Antibacterial, Antitumor, Bacillus sp., Secondary metabolite, Structure analysis",

author = "Ye Yang and Min Wang and Zhang, {Ting Ting} and Yin Cai and Ran Bi and Chen Luo",

year = "2008",

month = aug,

language = "English",

volume = "39",

pages = "368--372",

journal = "Journal of China Pharmaceutical University",

issn = "1000-5048",

publisher = "China Pharmaceutical University",

number = "4",

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TY - JOUR

T1 - Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite

AU - Yang, Ye

AU - Wang, Min

AU - Zhang, Ting Ting

AU - Cai, Yin

AU - Bi, Ran

AU - Luo, Chen

PY - 2008/8

Y1 - 2008/8

N2 - Aim: To identify the isolated strain from the soil sample obtained near the yellow sea beach and to investigate the antibacterial and antitumor activities of its secondary metabolite as well as its structural information. Methods: The 16s r DNA and morphological characteristics of the isolated strain were investigated. BSC, the secondary metabolite of the strain, was also studied for its antibacterial and antitumor activities, as well as its structure. Results: Based on the 16s rDNA and morphological features, this new strain was confirmed to be Bacillus sp., BSC effectively inhibited the growth of bacterial and tumor cells in vitro, and the molecular formula of BSC is C48 H94 O19. Conclusion: The isolated strain belongs to Bacillus sp. BSC has fair antibacterial and antitumor activities, and it is one potential antibiotic.

AB - Aim: To identify the isolated strain from the soil sample obtained near the yellow sea beach and to investigate the antibacterial and antitumor activities of its secondary metabolite as well as its structural information. Methods: The 16s r DNA and morphological characteristics of the isolated strain were investigated. BSC, the secondary metabolite of the strain, was also studied for its antibacterial and antitumor activities, as well as its structure. Results: Based on the 16s rDNA and morphological features, this new strain was confirmed to be Bacillus sp., BSC effectively inhibited the growth of bacterial and tumor cells in vitro, and the molecular formula of BSC is C48 H94 O19. Conclusion: The isolated strain belongs to Bacillus sp. BSC has fair antibacterial and antitumor activities, and it is one potential antibiotic.

KW - Antibacterial

KW - Antitumor

KW - Bacillus sp.

KW - Secondary metabolite

KW - Structure analysis

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M3 - Journal article

AN - SCOPUS:51349161261

SN - 1000-5048

VL - 39

SP - 368

EP - 372

JO - Journal of China Pharmaceutical University

JF - Journal of China Pharmaceutical University

IS - 4

ER -

Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite

Abstract

Keywords

ASJC Scopus subject areas

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