Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite

Ye Yang, Min Wang, Ting Ting Zhang, Yin Cai, Ran Bi, Chen Luo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Aim: To identify the isolated strain from the soil sample obtained near the yellow sea beach and to investigate the antibacterial and antitumor activities of its secondary metabolite as well as its structural information. Methods: The 16s r DNA and morphological characteristics of the isolated strain were investigated. BSC, the secondary metabolite of the strain, was also studied for its antibacterial and antitumor activities, as well as its structure. Results: Based on the 16s rDNA and morphological features, this new strain was confirmed to be Bacillus sp., BSC effectively inhibited the growth of bacterial and tumor cells in vitro, and the molecular formula of BSC is C48 H94 O19. Conclusion: The isolated strain belongs to Bacillus sp. BSC has fair antibacterial and antitumor activities, and it is one potential antibiotic.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalJournal of China Pharmaceutical University
Volume39
Issue number4
Publication statusPublished - Aug 2008
Externally publishedYes

Keywords

  • Antibacterial
  • Antitumor
  • Bacillus sp.
  • Secondary metabolite
  • Structure analysis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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