Abstract
The entry of lymphocytes into normal lymph nodes occurs principally after their passage across postcapillary high endothelial venules. Nonlymphoidal tissues do not normally express high endothelial venules; however, in inflammatory rheumatic diseases associated with prominent lymphocyte accumulation (e.g., rheumatoid synovium), high endothelial venule-like structures are found and may facilitate local lymphocyte traffic. In mouse and man there are lymphocyte surface membrane homing receptors which determine lymphocyte binding to acceptor sites on lymph node high endothelial venules. The migration of lymphocytes from the circulation into inflamed nonlymphoidal tissues may be controlled by similar homing receptor mediated mechanisms.
Original language | English |
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Pages (from-to) | 194-196 |
Number of pages | 3 |
Journal | Journal of Rheumatology |
Volume | 14 |
Issue number | 2 |
Publication status | Published - 25 Sept 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Rheumatology
- Immunology