Huperzine A ameliorates the spatial working memory impairments induced by AF64A

Zhi Qi Xiong, Yifan Han, Xi Can Tang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

26 Citations (Scopus)


Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer’s disease. We have assessed the effects of huperzine A on performance of AF64A-treated rats in the radial maze. AF64A (2 nmol per side, i.e.v.) caused significant impairment in rats’ ability to perform the spatial working memory task. This behavioural impairment was associated with a significant decrease in the activity of choline acetyltransferase (ChAT) in the hippocampus. Huperzine A (0.4-0.5 mg kg"1, i.p.) significantly ameliorated the AF64A-induced memory deficit. These results suggest that AF64A is a useful agent for disrupting working memory processes by altering hippocampal cholinergic function, and such impairment can be effectively ameliorated by huperzine A.
Original languageEnglish
Pages (from-to)2221-2224
Number of pages4
Issue number16
Publication statusPublished - 1 Jan 1995
Externally publishedYes


  • Alzheimer’s disease
  • Cholinesterase inhibitors
  • Huperzine A
  • Memory

ASJC Scopus subject areas

  • General Neuroscience


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